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Exportin 1
Exportin1, CRM1, free form.jpg
PDB rendering based on 4FGV.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols XPO1 ; CRM1; emb; exp1
External IDs OMIM602559 MGI2144013 HomoloGene2554 ChEMBL: 5661 GeneCards: XPO1 Gene
RNA expression pattern
PBB GE XPO1 208775 at tn.png
More reference expression data
Species Human Mouse
Entrez 7514 103573
Ensembl ENSG00000082898 ENSMUSG00000020290
UniProt O14980 Q6P5F9
RefSeq (mRNA) NM_003400 NM_001035226
RefSeq (protein) NP_003391 NP_001030303
Location (UCSC) Chr 2:
61.7 – 61.77 Mb
Chr 11:
23.26 – 23.3 Mb
PubMed search [1] [2]

Exportin-1 is a protein that in humans is encoded by the XPO1 gene.[1][2]

The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.[3]


XPO1 has been shown to interact with NMD3,[4] CIITA,[5][6] RANBP3,[7][8] Nucleoporin 62,[7][9] Ran,[10][11][12] RANBP1,[12][13] APC,[10] SMARCB1,[14] p53,[15][16] and CDKN1B.[17][18]

See also[edit]


  1. ^ Fornerod M, van Baal S, Valentine V, Shapiro DN, Grosveld G (September 1997). "Chromosomal localization of genes encoding CAN/Nup214-interacting proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to 17p13 and is physically linked to SF2p32". Genomics 42 (3): 538–40. doi:10.1006/geno.1997.4767. PMID 9205132. 
  2. ^ Kudo N, Khochbin S, Nishi K, Kitano K, Yanagida M, Yoshida M, Horinouchi S (Dec 1997). "Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins". J Biol Chem 272 (47): 29742–51. doi:10.1074/jbc.272.47.29742. PMID 9368044. 
  3. ^ "Entrez Gene: XPO1 exportin 1 (CRM1 homolog, yeast)". 
  4. ^ Thomas, Franziska; Kutay Ulrike (June 2003). "Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway". J. Cell. Sci. (England) 116 (Pt 12): 2409–19. doi:10.1242/jcs.00464. ISSN 0021-9533. PMID 12724356. 
  5. ^ Raval, Aparna; Weissman Jocelyn D; Howcroft T Kevin; Singer Dinah S (January 2003). "The GTP-binding domain of class II transactivator regulates its nuclear export". J. Immunol. (United States) 170 (2): 922–30. doi:10.4049/jimmunol.170.2.922. ISSN 0022-1767. PMID 12517958. 
  6. ^ Voong, Lilien N; Slater Allison R; Kratovac Sebila; Cressman Drew E (April 2008). "Mitogen-activated protein kinase ERK1/2 regulates the class II transactivator". J. Biol. Chem. (United States) 283 (14): 9031–9. doi:10.1074/jbc.M706487200. ISSN 0021-9258. PMC 2431044. PMID 18245089. 
  7. ^ a b Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. (United States) 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN 0021-9525. PMC 2150735. PMID 11425870. 
  8. ^ Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell (United States) 110 (3): 349–60. doi:10.1016/S0092-8674(02)00836-X. ISSN 0092-8674. PMID 12176322. 
  9. ^ Kehlenbach, R H; Dickmanns A; Kehlenbach A; Guan T; Gerace L (May 1999). "A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export". J. Cell Biol. (UNITED STATES) 145 (4): 645–57. doi:10.1083/jcb.145.4.645. ISSN 0021-9525. PMC 2133185. PMID 10330396. 
  10. ^ a b Tickenbrock, Lara; Cramer Janina; Vetter Ingrid R; Muller Oliver (August 2002). "The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1)". J. Biol. Chem. (United States) 277 (35): 32332–8. doi:10.1074/jbc.M203990200. ISSN 0021-9258. PMID 12070164. 
  11. ^ Fornerod, M; Ohno M; Yoshida M; Mattaj I W (September 1997). "CRM1 is an export receptor for leucine-rich nuclear export signals". Cell (UNITED STATES) 90 (6): 1051–60. doi:10.1016/S0092-8674(00)80371-2. ISSN 0092-8674. PMID 9323133. 
  12. ^ a b Plafker, K; Macara I G (May 2000). "Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1". Mol. Cell. Biol. (UNITED STATES) 20 (10): 3510–21. doi:10.1128/MCB.20.10.3510-3521.2000. ISSN 0270-7306. PMC 85643. PMID 10779340. 
  13. ^ Singh, B B; Patel H H; Roepman R; Schick D; Ferreira P A (Dec 1999). "The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1". J. Biol. Chem. (UNITED STATES) 274 (52): 37370–8. doi:10.1074/jbc.274.52.37370. ISSN 0021-9258. PMID 10601307. 
  14. ^ Craig, Errol; Zhang Zhi-Kai; Davies Kelvin P; Kalpana Ganjam V (January 2002). "A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis". EMBO J. (England) 21 (1-2): 31–42. doi:10.1093/emboj/21.1.31. ISSN 0261-4189. PMC 125819. PMID 11782423. 
  15. ^ Kanai, Masayuki; Kazuhiko Hanashiro, Song-Hee Kim, Shuji Hanai, A. Hamid Boulares, Masanao Miwa, Kenji Fukasawa V (September 2007). "Inhibition of Crm1–p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation". Nature Cell Biology (United States) 9: 1175–1183. doi:10.1038/ncb1638. ISSN 1465-7392. PMID 17891139. 
  16. ^ Shao, Changxia; Chuanwen Lu, Lixia Chen, Patrick P. Koty, Everardo Cobos and Weimin Gao V (August 2010). "p53-dependent anticancer effects of leptomycin B on lung adenocarcinoma". Cancer Chemotherapy and Pharmacology (United States) 67 (6): 1369–1380. doi:10.1007/s00280-010-1434-6. ISSN 0344-5704. PMID 20803015. 
  17. ^ Ishida, Noriko; Hara Taichi; Kamura Takumi; Yoshida Minoru; Nakayama Keiko; Nakayama Keiichi I (April 2002). "Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export". J. Biol. Chem. (United States) 277 (17): 14355–8. doi:10.1074/jbc.C100762200. ISSN 0021-9258. PMID 11889117. 
  18. ^ Connor, Michael K; Kotchetkov Rouslan; Cariou Sandrine; Resch Ansgar; Lupetti Rafaella; Beniston Richard G; Melchior Frauke; Hengst Ludger; Slingerland Joyce M (January 2003). "CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis". Mol. Biol. Cell (United States) 14 (1): 201–13. doi:10.1091/mbc.E02-06-0319. ISSN 1059-1524. PMC 140238. PMID 12529437. 

Further reading[edit]

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