XPOT
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| Exportin, tRNA (nuclear export receptor for tRNAs) | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | XPOT; XPO3 | ||||||||||||
| External IDs | OMIM: 603180 MGI: 1920442 HomoloGene: 38291 GeneCards: XPOT Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11260 | 73192 | |||||||||||
| Ensembl | ENSG00000184575 | ENSMUSG00000034667 | |||||||||||
| UniProt | O43592 | Q9CRT8 | |||||||||||
| RefSeq (mRNA) | NM_007235 | NM_001081056.1 | |||||||||||
| RefSeq (protein) | NP_009166 | NP_001074525.1 | |||||||||||
| Location (UCSC) | Chr 12: 64.8 – 64.84 Mb |
Chr 10: 121.02 – 121.06 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Exportin-T is a protein that in humans is encoded by the XPOT gene.[1][2][3]
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.[3]
[edit] References
- ^ Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Gorlich D (Jul 1998). "Identification of a tRNA-specific nuclear export receptor". Mol Cell 1 (3): 359–69. doi:10.1016/S1097-2765(00)80036-2. PMID 9660920.
- ^ Arts GJ, Fornerod M, Mattaj IW (May 1998). "Identification of a nuclear export receptor for tRNA". Curr Biol 8 (6): 305–14. doi:10.1016/S0960-9822(98)70130-7. PMID 9512417.
- ^ a b "Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11260.
[edit] Further reading
- Arts GJ, Kuersten S, Romby P, et al. (1999). "The role of exportin-t in selective nuclear export of mature tRNAs.". EMBO J. 17 (24): 7430–41. doi:10.1093/emboj/17.24.7430. PMC 1171087. PMID 9857198. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171087.
- Kruse C, Willkomm DK, Grünweller A, et al. (2000). "Export and transport of tRNA are coupled to a multi-protein complex.". Biochem. J. 346 (1): 107–15. doi:10.1042/0264-6021:3460107. PMC 1220829. PMID 10657246. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220829.
- Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.". J. Biol. Chem. 275 (51): 40163–8. doi:10.1074/jbc.M006242200. PMID 11024021.
- Kuersten S, Arts GJ, Walther TC, et al. (2002). "Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains.". Mol. Cell. Biol. 22 (16): 5708–20. doi:10.1128/MCB.22.16.5708-5720.2002. PMC 133969. PMID 12138183. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133969.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Suzuki T, Koyama Y, Hayakawa S, et al. (2006). "1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.". Biomed. Res. 27 (2): 89–92. doi:10.2220/biomedres.27.89. PMID 16707848.
- Li S, Sprinzl M (2007). "Interaction of immobilized human exportin-t with calf liver tRNA.". RNA Biol 3 (4): 145–9. PMID 17224653.
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