XRCC2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
X-ray repair complementing defective repair in Chinese hamster cells 2
Identifiers
Symbols XRCC2 ; DKFZp781P0919
External IDs OMIM600375 MGI1927345 HomoloGene3964 GeneCards: XRCC2 Gene
RNA expression pattern
PBB GE XRCC2 207598 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7516 57434
Ensembl ENSG00000196584 ENSMUSG00000028933
UniProt O43543 Q9CX47
RefSeq (mRNA) NM_005431 NM_020570
RefSeq (protein) NP_005422 NP_065595
Location (UCSC) Chr 7:
152.34 – 152.37 Mb
Chr 5:
25.69 – 25.71 Mb
PubMed search [1] [2]

DNA repair protein XRCC2 is a protein that in humans is encoded by the XRCC2 gene.[1][2][3]

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.[3]

Interactions[edit]

XRCC2 has been shown to interact with RAD51L3,[4][5][6][7] Bloom syndrome protein[5] and RAD51C.[7][8]

References[edit]

  1. ^ Jones NJ, Zhao Y, Siciliano MJ, Thompson LH (August 1995). "Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by complementation analysis". Genomics 26 (3): 619–22. doi:10.1016/0888-7543(95)80187-Q. PMID 7607692. 
  2. ^ Cui X, Brenneman M, Meyne J, Oshimura M, Goodwin EH, Chen DJ (August 1999). "The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells". Mutat Res 434 (2): 75–88. doi:10.1016/s0921-8777(99)00010-5. PMID 10422536. 
  3. ^ a b "Entrez Gene: XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2". 
  4. ^ Schild, D; Lio Y C; Collins D W; Tsomondo T; Chen D J (June 2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". J. Biol. Chem. (UNITED STATES) 275 (22): 16443–9. doi:10.1074/jbc.M001473200. ISSN 0021-9258. PMID 10749867. 
  5. ^ a b Braybrooke, Jeremy P; Li Ji-Liang; Wu Leonard; Caple Fiona; Benson Fiona E; Hickson Ian D (November 2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem. (United States) 278 (48): 48357–66. doi:10.1074/jbc.M308838200. ISSN 0021-9258. PMID 12975363. 
  6. ^ Hussain, Shobbir; Wilson James B, Medhurst Annette L, Hejna James, Witt Emily, Ananth Sahana, Davies Adelina, Masson Jean-Yves, Moses Robb, West Stephen C, de Winter Johan P, Ashworth Alan, Jones Nigel J, Mathew Christopher G (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. (England) 13 (12): 1241–8. doi:10.1093/hmg/ddh135. ISSN 0964-6906. PMID 15115758. 
  7. ^ a b Liu, Nan; Schild David; Thelen Michael P; Thompson Larry H (February 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. (England) 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113. 
  8. ^ Miller, Kristi A; Yoshikawa Daniel M; McConnell Ian R; Clark Robin; Schild David; Albala Joanna S (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. (United States) 277 (10): 8406–11. doi:10.1074/jbc.M108306200. ISSN 0021-9258. PMID 11744692. 

Further reading[edit]