XRCC3

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X-ray repair complementing defective repair in Chinese hamster cells 3
Identifiers
Symbols XRCC3 ; CMM6
External IDs OMIM600675 MGI1921585 HomoloGene36178 GeneCards: XRCC3 Gene
RNA expression pattern
PBB GE XRCC3 216299 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7517 74335
Ensembl ENSG00000126215 ENSMUSG00000021287
UniProt O43542 Q9CXE6
RefSeq (mRNA) NM_001100118 NM_028875
RefSeq (protein) NP_001093588 NP_083151
Location (UCSC) Chr 14:
104.16 – 104.18 Mb
Chr 12:
111.8 – 111.81 Mb
PubMed search [1] [2]

DNA repair protein XRCC3 is a protein that in humans is encoded by the XRCC3 gene.[1]

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.[2]

Interactions[edit]

XRCC3 has been shown to interact with RAD51C.[3][4][5][6]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 

References[edit]

  1. ^ Tebbs RS, Zhao Y, Tucker JD, Scheerer JB, Siciliano MJ, Hwang M, Liu N, Legerski RJ, Thompson LH (August 1995). "Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene". Proc Natl Acad Sci U S A 92 (14): 6354–6358. doi:10.1073/pnas.92.14.6354. PMC 41516. PMID 7603995. 
  2. ^ "Entrez Gene: XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3". 
  3. ^ Hussain, Shobbir; Wilson James B, Medhurst Annette L, Hejna James, Witt Emily, Ananth Sahana, Davies Adelina, Masson Jean-Yves, Moses Robb, West Stephen C, de Winter Johan P, Ashworth Alan, Jones Nigel J, Mathew Christopher G (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. (England) 13 (12): 1241–1248. doi:10.1093/hmg/ddh135. ISSN 0964-6906. PMID 15115758. 
  4. ^ Miller, Kristi A; Yoshikawa Daniel M, McConnell Ian R, Clark Robin, Schild David, Albala Joanna S (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. (United States) 277 (10): 8406–8411. doi:10.1074/jbc.M108306200. ISSN 0021-9258. PMID 11744692. 
  5. ^ Liu, Nan; Schild David, Thelen Michael P, Thompson Larry H (February 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. (England) 30 (4): 1009–1015. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113. 
  6. ^ Kurumizaka, H; Ikawa S, Nakada M, Eda K, Kagawa W, Takata M, Takeda S, Yokoyama S, Shibata T (May 2001). "Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (10): 5538–5543. doi:10.1073/pnas.091603098. ISSN 0027-8424. PMC 33248. PMID 11331762. 

Further reading[edit]