XYLT1

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Xylosyltransferase I
Identifiers
Symbols XYLT1 ; DBQD2; PXYLT1; XT-I; XT1; XTI; XYLTI
External IDs OMIM608124 MGI2451073 HomoloGene32534 GeneCards: XYLT1 Gene
EC number 2.4.2.26
Orthologs
Species Human Mouse
Entrez 64131 233781
Ensembl ENSG00000103489 ENSMUSG00000030657
UniProt Q86Y38 Q811B1
RefSeq (mRNA) NM_022166 NM_175645
RefSeq (protein) NP_071449 NP_783576
Location (UCSC) Chr 16:
17.2 – 17.56 Mb
Chr 7:
117.38 – 117.67 Mb
PubMed search [1] [2]

Xylosyltransferase 1 is an enzyme that in humans is encoded by the XYLT1 gene.[1][2]

Xylosyltransferase (XT; EC 2.4.2.26) catalyzes the transfer of UDP-xylose to serine residues within XT recognition sequences of target proteins. Addition of this xylose to the core protein is required for the biosynthesis of the glycosaminoglycan chains characteristic of proteoglycans.[supplied by OMIM][2]

References[edit]

  1. ^ Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K (Jan 2001). "Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II". J Mol Biol 304 (4): 517–28. doi:10.1006/jmbi.2000.4261. PMID 11099377. 
  2. ^ a b "Entrez Gene: XYLT1 xylosyltransferase I". 

Further reading[edit]