Xanthosine monophosphate
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| Xanthosine monophosphate | |
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5'-xanthylic acid |
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Other names
xanthine ribotide, |
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| Identifiers | |
| CAS number | 523-98-8 |
| PubChem | 122280 |
| MeSH | Xanthosine+monophosphate |
| Properties | |
| Molecular formula | C10H13N4O9P |
| Molar mass | 364.206 g/mol |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Xanthosine monophosphate is an intermediate in purine metabolism. It is a ribonucleoside monophosphate. It is formed from IMP via the action of IMP dehydrogenase, and it forms GMP via the action of GMP synthase.
[edit] Clinical significance
Xanthylic acid can be used in quantitative measurements of the inosine monophosphate dehydrogenase enzyme activities in purine metabolism, as recommended to ensure optimal thiopurine therapy for children with acute lymphoblastic leukaemia (ALL).[1]
[edit] See also
[edit] References
- ^ Khalil PN, Erb N, Khalil MN, Escherich G, Janka-Schaub GE (September 2006). "Validation and application of a high-performance liquid chromatographic-based assay for determination of the inosine 5'-monophosphate dehydrogenase activity in erythrocytes". J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 842 (1): 1–7. doi:10.1016/j.jchromb.2006.04.040. PMID 16725387. http://linkinghub.elsevier.com/retrieve/pii/S1570-0232(06)00373-4.
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