|Systematic (IUPAC) name|
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Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor; it is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Veterinarians also use xylazine as an emetic, especially in cats.
In veterinary anesthesia, xylazine is often used in combination with ketamine. It is sold under many brand names worldwide, most notably the Bayer brand name Rompun. The drug interactions vary with different animals.
- Xylazine at drugs.com
- by Patricia M. Dowling & Johann (Hans) Coetzee for the Merck Manual. Last full review/revision March 2012 Drugs to Control or Stimulate Vomiting (Monogastric)
- Aithal, H. P., Amarpal K. Pratap, and G. R. Singh. "Clinical effects of epidurally administered ketamine and xylazine in goats." Small Ruminant Research 24.1 (1997): 55-64.
- Haskins, S. C., J. D. Patz, and T. B. Farver. "Xylazine and xylazine-ketamine in dogs." American journal of veterinary research 47.3 (1986): 636-641.
- Muir, W. W., R. T. Skarda, and D. W. Milne. "Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses." American journal of veterinary research 38.2 (1977): 195-201.
- Torruella, R.A. "Xylazine (veterinary sedative) use in Puerto Rico." Substance Abuse Treatment Prevention Policy, April 11, 2011, 6:7. doi:10.1186/1747-597X-6-7
- Reyes, J.C. et. al. "The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico." Journal of Urban Health, June 2012, 89 (3): 519-526. doi:10.1007/s11524-011-9662-6
- McCurnin, DM, and JM Bassert. Clinical Textbook for Veterinary Technicians, 5th ed. Saunders, Philadelphia, PA. 2002.
- Bayer Healthcare - Rompun Homepage http://www.rompun.com/. 2005.
- Wright, Dr. Bob. Human Health Concerns When Working With Medications Around Horses. Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA). http://www.omafra.gov.on.ca/english/livestock/horses/facts/00-063.html. 2005.
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