Xylazine

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Xylazine
Xylazin.svg
Systematic (IUPAC) name
N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Identifiers
CAS number 7361-61-7 YesY
ATCvet code QN05CM92
PubChem CID 5707
IUPHAR ligand 523
ChemSpider 5505 N
UNII 2KFG9TP5V8 YesY
KEGG D08683 YesY
ChEMBL CHEMBL297362 N
Chemical data
Formula C12H16N2S 
Mol. mass 220.33
 N (what is this?)  (verify)

Xylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico.[1]

As with other α2 agonists, adverse effects include bradycardia, conduction disturbances, and myocardial depression. Yohimbine (Yobine), tolazoline (commercial name Tolazine), and atipamezole (commercial name Antisedan) can be used to reverse xylazine effects. In veterinary anesthesia, xylazine is often used in combination with ketamine. No formal information in humans is available. Xylazine is sold by Bayer under the brand name Rompun.

Xylazine is also used to shorten the effects of musth on male elephants in Asia.

Veterinary indications[edit]

Veterinarians use xylazine as an emetic when it is desirable to remove a substance from a cat's stomach. In one trial,[citation needed] pilocarpine was used instead of xylazine.

References[edit]

  1. ^ Reyes, J. C.; Negrón, J. L.; Colón, H. M.; Padilla, A. M.; Millán, M. Y.; Matos, T. D.; Robles, R. R. (2012). "The Emerging of Xylazine as a New Drug of Abuse and its Health Consequences among Drug Users in Puerto Rico". Journal of Urban Health 89 (3): 519–526. doi:10.1007/s11524-011-9662-6. PMC 3368046. PMID 22391983.  edit