Xylazine

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Xylazine
Xylazin.svg
Systematic (IUPAC) name
N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Identifiers
CAS number 7361-61-7 YesY
ATCvet code QN05CM92
PubChem CID 5707
IUPHAR ligand 523
ChemSpider 5505 N
UNII 2KFG9TP5V8 YesY
KEGG D08683 YesY
ChEMBL CHEMBL297362 N
Chemical data
Formula C12H16N2S 
Mol. mass 220.33
 N (what is this?)  (verify)

Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor; it is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.[1] Veterinarians also use xylazine as an emetic, especially in cats.[2]

In veterinary anesthesia, xylazine is often used in combination with ketamine. The drug interactions vary with different animals.[3][4][5]

It is sold under many brand names worldwide, most notably the Bayer brand name Rompun.[1]

References[edit]

  1. ^ a b Xylazine at drugs.com
  2. ^ by Patricia M. Dowling & Johann (Hans) Coetzee for the Merck Manual. Last full review/revision March 2012 Drugs to Control or Stimulate Vomiting (Monogastric)
  3. ^ Aithal, H. P., Amarpal K. Pratap, and G. R. Singh. "Clinical effects of epidurally administered ketamine and xylazine in goats." Small Ruminant Research 24.1 (1997): 55-64.
  4. ^ Haskins, S. C., J. D. Patz, and T. B. Farver. "Xylazine and xylazine-ketamine in dogs." American journal of veterinary research 47.3 (1986): 636-641.
  5. ^ Muir, W. W., R. T. Skarda, and D. W. Milne. "Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses." American journal of veterinary research 38.2 (1977): 195-201.