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Xystus has several meanings:
- Xystus, a Greek architectural term denoting the covered portico of a gymnasium
- Xystus, another spelling for the Roman name Sixtus
- Pope St. Xystus I
- Pope St. Xystus II
- Pope St. Xystus III
- Xystus, a Greek student of Pythagoreanism with whom the authors of the Liber Pontificalis perhaps conflated Xystus I
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