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YY1 associated factor 2
Protein YAF2 PDB 2d9g.png
PDB rendering based on 2d9g.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols YAF2 ; DKFZp779H1820; MGC41856
External IDs OMIM607534 MGI1914307 HomoloGene136401 GeneCards: YAF2 Gene
RNA expression pattern
PBB GE YAF2 206238 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10138 67057
Ensembl ENSG00000015153 ENSMUSG00000022634
UniProt Q8IY57 Q99LW6
RefSeq (mRNA) NM_001012424 NM_024189
RefSeq (protein) NP_001177906 NP_077151
Location (UCSC) Chr 12:
42.55 – 42.63 Mb
Chr 15:
93.28 – 93.34 Mb
PubMed search [1] [2]

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.[1][2]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.[2]


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