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Not to be confused with RS-24 Yars.
Tyrosyl-tRNA synthetase
Protein YARS PDB 1n3l.png
PDB rendering based on 1n3l.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603623 MGI2147627 HomoloGene2730 ChEMBL: 3179 GeneCards: YARS Gene
EC number
RNA expression pattern
PBB GE YARS 212048 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8565 107271
Ensembl ENSG00000134684 ENSMUSG00000028811
UniProt P54577 Q91WQ3
RefSeq (mRNA) NM_003680 NM_134151
RefSeq (protein) NP_003671 NP_598912
Location (UCSC) Chr 1:
33.24 – 33.28 Mb
Chr 4:
129.19 – 129.22 Mb
PubMed search [1] [2]

Tyrosyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the YARS gene.[1][2][3]

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.[3]


  1. ^ Ribas de Pouplana L, Frugier M, Quinn CL, Schimmel P (Feb 1996). "Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria". Proc Natl Acad Sci U S A 93 (1): 166–70. doi:10.1073/pnas.93.1.166. PMC 40199. PMID 8552597. 
  2. ^ Kleeman TA, Wei D, Simpson KL, First EA (Jun 1997). "Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine". J Biol Chem 272 (22): 14420–5. doi:10.1074/jbc.272.22.14420. PMID 9162081. 
  3. ^ a b "Entrez Gene: YARS tyrosyl-tRNA synthetase". 

Further reading[edit]