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YKT6 v-SNARE homolog (S. cerevisiae)
Symbol YKT6
External IDs OMIM606209 MGI1927550 HomoloGene4778 GeneCards: YKT6 Gene
RNA expression pattern
PBB GE YKT6 217785 s at tn.png
PBB GE YKT6 217784 at tn.png
More reference expression data
Species Human Mouse
Entrez 10652 56418
Ensembl ENSG00000106636 ENSMUSG00000002741
UniProt O15498 Q9CQW1
RefSeq (mRNA) NM_006555 NM_019661
RefSeq (protein) NP_006546 NP_062635
Location (UCSC) Chr 7:
44.24 – 44.25 Mb
Chr 11:
5.96 – 5.97 Mb
PubMed search [1] [2]

Synaptobrevin homolog YKT6 is a protein that in humans is encoded by the YKT6 gene.[1][2][3]

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway.[3]


YKT6 has been shown to interact with BET1L.[4][5]


  1. ^ Veit M (November 2004). "The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues". Biochem J 384 (Pt 2): 233–7. doi:10.1042/BJ20041474. PMC 1134105. PMID 15479160. 
  2. ^ Rossi V, Banfield DK, Vacca M, Dietrich LE, Ungermann C, D'Esposito M, Galli T, Filippini F (November 2004). "Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators". Trends Biochem Sci 29 (12): 682–8. doi:10.1016/j.tibs.2004.10.002. PMID 15544955. 
  3. ^ a b "Entrez Gene: YKT6 YKT6 v-SNARE homolog (S. cerevisiae)". 
  4. ^ Shorter, James; Beard Matthew B, Seemann Joachim, Dirac-Svejstrup A Barbara, Warren Graham (April 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. (United States) 157 (1): 45–62. doi:10.1083/jcb.200112127. ISSN 0021-9525. PMC 2173270. PMID 11927603. 
  5. ^ Xu, Yue; Martin Sally; James David E; Hong Wanjin (October 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell (United States) 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. ISSN 1059-1524. PMC 129961. PMID 12388752. 

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