YME1L1

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YME1-like 1 (S. cerevisiae)
Identifiers
Symbols YME1L1 ; FTSH; MEG4; PAMP; YME1L
External IDs OMIM607472 MGI1351651 HomoloGene31996 GeneCards: YME1L1 Gene
RNA expression pattern
PBB GE YME1L1 201351 s at tn.png
PBB GE YME1L1 201352 at tn.png
PBB GE YME1L1 216304 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10730 27377
Ensembl ENSG00000136758 ENSMUSG00000026775
UniProt Q96TA2 O88967
RefSeq (mRNA) NM_001253866 NM_013771
RefSeq (protein) NP_001240795 NP_038799
Location (UCSC) Chr 10:
27.4 – 27.44 Mb
Chr 2:
23.16 – 23.2 Mb
PubMed search [1] [2]

ATP-dependent metalloprotease YME1L1 is an enzyme that in humans is encoded by the YME1L1 gene.[1]

The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Two transcript variants encoding different isoforms have been found for this gene.[1]

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