YWHAG

YWHAG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B05, 3UZD, 4E2E, 4J6S, 4O46, 5D3E
Identifiers
Aliases	YWHAG, 14-3-3GAMMA, PPP1R170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, EIEE56, DEE56
External IDs	OMIM: 605356 MGI: 108109 HomoloGene: 22725 GeneCards: YWHAG
Gene location (Human)
Chr.	Chromosome 7 (human)
End	76,358,991 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,963,470 bp
RNA expression pattern
	Top expressed in
	pons; ; Brodmann area 23; ; spinal ganglia; ; superior vestibular nucleus; ; middle temporal gyrus; ; endothelial cell; ; Brodmann area 46; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus;
	Top expressed in
	entorhinal cortex; ; primary motor cortex; ; dorsomedial hypothalamic nucleus; ; dorsal tegmental nucleus; ; ventral tegmental area; ; subiculum; ; ventromedial nucleus; ; medial dorsal nucleus; ; cingulate gyrus; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	insulin-like growth factor receptor binding; protein domain specific binding; receptor tyrosine kinase binding; protein binding; protein kinase C binding; protein kinase C inhibitor activity; RNA binding; identical protein binding;
Cellular component	cytoplasm; cytosol; membrane; focal adhesion; myelin sheath; extracellular exosome; cytoplasmic vesicle membrane; mitochondrion; vesicle; synapse; presynapse;
Biological process	regulation of neuron differentiation; protein targeting; negative regulation of protein kinase activity; regulation of synaptic plasticity; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of signal transduction; G2/M transition of mitotic cell cycle; cellular response to insulin stimulus; membrane organization; negative regulation of protein serine/threonine kinase activity; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	7532
	22628
	ENSG00000170027
	ENSMUSG00000051391
	P61981
	P61982
	NM_012479
	NM_018871
	NP_036611
	NP_061359
	Wikidata
View/Edit Human	View/Edit Mouse

14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene.^[5]^[6]

This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.^[7]

Interactions[edit]

YWHAG has been shown to interact with C-Raf,^[6]^[8]^[9] EPB41L3,^[8]^[10] KIF1C^[11] and Stratifin.^[12]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170027 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051391 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Horie M, Suzuki M, Takahashi E, Tanigami A (September 1999). "Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23". Genomics. 60 (2): 241–3. doi:10.1006/geno.1999.5887. PMID 10486217.
^ ^a ^b Autieri MV, Carbone CJ (July 1999). "14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells". DNA and Cell Biology. 18 (7): 555–64. doi:10.1089/104454999315105. PMID 10433554.
^ "Entrez Gene: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide".
^ ^a ^b Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Dijk MC, Van Blitterswijk J (January 2000). "14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation". The Biochemical Journal. 345 Pt 2 (2): 297–306. doi:10.1042/0264-6021:3450297. PMC 1220759. PMID 10620507.
^ Yu T, Robb VA, Singh V, Gutmann DH, Newsham IF (August 2002). "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins". The Biochemical Journal. 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. PMC 1222735. PMID 11996670.
^ Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". The Journal of Biological Chemistry. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.
^ Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.

External links[edit]

Overview of all the structural information available in the PDB for UniProt: P61981 (14-3-3 protein gamma (YWHAG)) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170027 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051391 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10486217-5] Horie M, Suzuki M, Takahashi E, Tanigami A (September 1999). "Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23". Genomics. 60 (2): 241–3. doi:10.1006/geno.1999.5887. PMID 10486217.

[pmid10433554-6] Autieri MV, Carbone CJ (July 1999). "14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells". DNA and Cell Biology. 18 (7): 555–64. doi:10.1089/104454999315105. PMID 10433554.

[entrez-7] "Entrez Gene: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide".

[pmid17353931-8] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid10620507-9] Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Dijk MC, Van Blitterswijk J (January 2000). "14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation". The Biochemical Journal. 345 Pt 2 (2): 297–306. doi:10.1042/0264-6021:3450297. PMC 1220759. PMID 10620507.

[pmid11996670-10] Yu T, Robb VA, Singh V, Gutmann DH, Newsham IF (August 2002). "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins". The Biochemical Journal. 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. PMC 1222735. PMID 11996670.

[pmid10559254-11] Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". The Journal of Biological Chemistry. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.

[pmid15778465-12] Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.

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Interactions[edit]

References[edit]

Further reading[edit]

External links[edit]