YWHAH

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
	; PDB rendering based on 2c63.
Available structures
PDB	2C63, 2C74
Identifiers
Symbols	YWHAH; YWHA1
External IDs	OMIM: 113508 MGI: 109194 HomoloGene: 37767 GeneCards: YWHAH Gene
Gene Ontology
Molecular function	• actin binding; • insulin-like growth factor receptor binding; • protein binding; • enzyme binding; • protein domain specific binding; • glucocorticoid receptor binding;
Cellular component	• cytoplasm;
Biological process	• glucocorticoid catabolic process; • intracellular protein transport; • glucocorticoid receptor signaling pathway; • regulation of neuron differentiation; • positive regulation of transcription, DNA-dependent; • regulation of synaptic plasticity; • negative regulation of dendrite morphogenesis;
	Sources: Amigo / QuickGO
Orthologs

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14-3-3 protein eta is a protein that in humans is encoded by the YWHAH gene.

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia.^[1]

[edit] Interactions

YWHAH has been shown to interact with TNFAIP3,^[2]^[3] KLC3,^[4] C-Raf,^[3]^[4]^[5] Phosphoinositide-dependent kinase-1,^[6] RIMS2,^[7] KIF5B,^[4] RIMS1,^[7] CDC25B,^[8] ZFP36,^[9] EPB41L3,^[10] Glucocorticoid receptor^[11] and TLX2.^[12]

[edit] References

^ "Entrez Gene: YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7533.
^ De Valck, D; Heyninck K, Van Criekinge W, Vandenabeele P, Fiers W, Beyaert R (Sep. 1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins". Biochem. Biophys. Res. Commun. (UNITED STATES) 238 (2): 590–4. doi:10.1006/bbrc.1997.7343. ISSN 0006-291X. PMID 9299557.
^ ^a ^b Vincenz, C; Dixit V M (Aug. 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. (UNITED STATES) 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. ISSN 0021-9258. PMID 8702721.
^ ^a ^b ^c Ichimura, Tohru; Wakamiya-Tsuruta Akiko, Itagaki Chiharu, Taoka Masato, Hayano Toshiya, Natsume Tohru, Isobe Toshiaki (Apr. 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry (United States) 41 (17): 5566–72. doi:10.1021/bi015946f. ISSN 0006-2960. PMID 11969417.
^ Van Der Hoeven, P C; Van Der Wal J C, Ruurs P, Van Dijk M C, Van Blitterswijk J (Jan. 2000). "14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation". Biochem. J. (ENGLAND) 345 Pt 2: 297–306. ISSN 0264-6021. PMC 1220759. PMID 10620507. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220759.
^ Sato, Saori; Fujita Naoya, Tsuruo Takashi (Oct. 2002). "Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3". J. Biol. Chem. (United States) 277 (42): 39360–7. doi:10.1074/jbc.M205141200. ISSN 0021-9258. PMID 12177059.
^ ^a ^b Sun, Lei; Bittner Mary A, Holz Ronald W (Oct. 2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus". J. Biol. Chem. (United States) 278 (40): 38301–9. doi:10.1074/jbc.M212801200. ISSN 0021-9258. PMID 12871946.
^ Mils, V; Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (Mar. 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene (ENGLAND) 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. ISSN 0950-9232. PMID 10713667.
^ Johnson, Barbra A; Stehn Justine R, Yaffe Michael B, Blackwell T Keith (May. 2002). "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms". J. Biol. Chem. (United States) 277 (20): 18029–36. doi:10.1074/jbc.M110465200. ISSN 0021-9258. PMID 11886850.
^ Yu, Tingxi; Robb Victoria A, Singh Vinita, Gutmann David H, Newsham Irene F (Aug. 2002). "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins". Biochem. J. (England) 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. ISSN 0264-6021. PMC 1222735. PMID 11996670. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222735.
^ Wakui, H; Wright A P, Gustafsson J, Zilliacus J (Mar. 1997). "Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein". J. Biol. Chem. (UNITED STATES) 272 (13): 8153–6. doi:10.1074/jbc.272.13.8153. ISSN 0021-9258. PMID 9079630.
^ Tang, S J; Suen T C, McInnes R R, Buchwald M (Sep. 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". J. Biol. Chem. (UNITED STATES) 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. ISSN 0021-9258. PMID 9738002.

[edit] Further reading

Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
Ichimura-Ohshima Y, Morii K, Ichimura T, et al. (1992). "cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain.". J. Neurosci. Res. 31 (4): 600–5. doi:10.1002/jnr.490310403. PMID 1578511.
Ichimura T, Isobe T, Okuyama T, et al. (1988). "Molecular cloning of cDNA coding for brain-specific 14-3-3 protein, a protein kinase-dependent activator of tyrosine and tryptophan hydroxylases.". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7084–8. doi:10.1073/pnas.85.19.7084. PMC 282128. PMID 2902623. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=282128.
Ichimura T, Uchiyama J, Kunihiro O, et al. (1996). "Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylase.". J. Biol. Chem. 270 (48): 28515–8. doi:10.1074/jbc.270.48.28515. PMID 7499362.
Jones DH, Ley S, Aitken A (1995). "Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins.". FEBS Lett. 368 (1): 55–8. doi:10.1016/0014-5793(95)00598-4. PMID 7615088.
Wu C, Friedlander P, Lamoureux C, et al. (1993). "cDNA clones contain autonomous replication activity.". Biochim. Biophys. Acta 1174 (3): 241–57. PMID 7690594.
Swanson KD, Dhar MS, Joshi JG (1993). "The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions.". Biochim. Biophys. Acta 1216 (1): 145–8. PMID 8218406.
Leffers H, Madsen P, Rasmussen HH, et al. (1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.". J. Mol. Biol. 231 (4): 982–98. doi:10.1006/jmbi.1993.1346. PMID 8515476.
Muratake T, Hayashi S, Ichimura Y, et al. (1996). "The effect on methamphetamine on the mRNA level for 14.3.3 eta chain in the human cultured cells.". Mol. Neurobiol. 11 (1-3): 223–30. doi:10.1007/BF02740697. PMID 8561965.
Tommerup N, Leffers H (1996). "Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization.". Genomics 33 (1): 149–50. doi:10.1006/geno.1996.0176. PMID 8617504.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Papin C, Denouel A, Calothy G, Eychène A (1996). "Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system.". Oncogene 12 (10): 2213–21. PMID 8668348.
Vincenz C, Dixit VM (1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules.". J. Biol. Chem. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. PMID 8702721.
Muratake T, Hayashi S, Ichikawa T, et al. (1997). "Structural organization and chromosomal assignment of the human 14-3-3 eta chain gene (YWHAH).". Genomics 36 (1): 63–9. doi:10.1006/geno.1996.0426. PMID 8812417.
Wakui H, Wright AP, Gustafsson J, Zilliacus J (1997). "Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein.". J. Biol. Chem. 272 (13): 8153–6. doi:10.1074/jbc.272.13.8153. PMID 9079630.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
Peng CY, Graves PR, Thoma RS, et al. (1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.". Science 277 (5331): 1501–5. doi:10.1126/science.277.5331.1501. PMID 9278512.
De Valck D, Heyninck K, Van Criekinge W, et al. (1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.". Biochem. Biophys. Res. Commun. 238 (2): 590–4. doi:10.1006/bbrc.1997.7343. PMID 9299557.
Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11.". Mol. Endocrinol. 11 (12): 1858–67. doi:10.1210/me.11.12.1858. PMID 9369453.

[0] "Entrez Gene: YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7533.

[pmid9299557-1] De Valck, D; Heyninck K, Van Criekinge W, Vandenabeele P, Fiers W, Beyaert R (Sep. 1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins". Biochem. Biophys. Res. Commun. (UNITED STATES) 238 (2): 590–4. doi:10.1006/bbrc.1997.7343. ISSN 0006-291X. PMID 9299557.

[pmid8702721-2] Vincenz, C; Dixit V M (Aug. 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. (UNITED STATES) 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. ISSN 0021-9258. PMID 8702721.

[pmid11969417-3] Ichimura, Tohru; Wakamiya-Tsuruta Akiko, Itagaki Chiharu, Taoka Masato, Hayano Toshiya, Natsume Tohru, Isobe Toshiaki (Apr. 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry (United States) 41 (17): 5566–72. doi:10.1021/bi015946f. ISSN 0006-2960. PMID 11969417.

[pmid10620507-4] Van Der Hoeven, P C; Van Der Wal J C, Ruurs P, Van Dijk M C, Van Blitterswijk J (Jan. 2000). "14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation". Biochem. J. (ENGLAND) 345 Pt 2: 297–306. ISSN 0264-6021. PMC 1220759. PMID 10620507. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220759.

[pmid12177059-5] Sato, Saori; Fujita Naoya, Tsuruo Takashi (Oct. 2002). "Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3". J. Biol. Chem. (United States) 277 (42): 39360–7. doi:10.1074/jbc.M205141200. ISSN 0021-9258. PMID 12177059.

[pmid12871946-6] Sun, Lei; Bittner Mary A, Holz Ronald W (Oct. 2003). "Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus". J. Biol. Chem. (United States) 278 (40): 38301–9. doi:10.1074/jbc.M212801200. ISSN 0021-9258. PMID 12871946.

[pmid10713667-7] Mils, V; Baldin V, Goubin F, Pinta I, Papin C, Waye M, Eychene A, Ducommun B (Mar. 2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene (ENGLAND) 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. ISSN 0950-9232. PMID 10713667.

[pmid11886850-8] Johnson, Barbra A; Stehn Justine R, Yaffe Michael B, Blackwell T Keith (May. 2002). "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms". J. Biol. Chem. (United States) 277 (20): 18029–36. doi:10.1074/jbc.M110465200. ISSN 0021-9258. PMID 11886850.

[pmid11996670-9] Yu, Tingxi; Robb Victoria A, Singh Vinita, Gutmann David H, Newsham Irene F (Aug. 2002). "The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins". Biochem. J. (England) 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. ISSN 0264-6021. PMC 1222735. PMID 11996670. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222735.

[pmid9079630-10] Wakui, H; Wright A P, Gustafsson J, Zilliacus J (Mar. 1997). "Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein". J. Biol. Chem. (UNITED STATES) 272 (13): 8153–6. doi:10.1074/jbc.272.13.8153. ISSN 0021-9258. PMID 9079630.

[pmid9738002-11] Tang, S J; Suen T C, McInnes R R, Buchwald M (Sep. 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". J. Biol. Chem. (UNITED STATES) 273 (39): 25356–63. doi:10.1074/jbc.273.39.25356. ISSN 0021-9258. PMID 9738002.

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YWHAH

[edit] Interactions

[edit] References

[edit] Further reading

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