Highlights from the museum's holdings include keyboard instruments from three centuries, featuring an organ by John Snetzler (London,1742), harpsichords by Ruckers (Antwerp, 1640), Blanchet (Paris, ca.1740), and Taskin (Paris, 1770), a clavichord by Hoffman (Ronneburg, 1784), and pianos by Könnicke (Vienna, ca. 1795), Boesendorfer (Vienna, ca. 1830), and Érard (Paris, 1883). The Collection possesses stringed instruments by Stradivari, Guarneri, and Stainer. Also included are a number of historical wind instruments, world instruments, and a large collection of bells given in 1975 by Robyna Neilson Ketchum.
The Collection maintains permanent exhibits, regularly mounts special exhibitions, and is open to the public during regular visiting hours. In addition to presentations made to Yale classes, the Collection offers tours and lecture-demonstrations to school and private groups by appointment.