Yeast U1 spliceosomal RNA

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Yeast U1 spliceosomal RNA
Predicted secondary structure and sequence conservation of U1_yeast
Symbol U1_yeast
Rfam RF00488
Other data
RNA type Gene; snRNA; splicing
Domain(s) Eukaryota
GO 0000368 0030627 0005685
SO 0000391

U1 is a small nuclear RNA (snRNA) component of the spliceosome and is involved in pre-mRNA splicing.

In the splicing process the 5' end of the U1 snRNA forms complementary base pairing with the 5' splice junction of the inton to be excised, thus defining the 5' donor site of an intron.

There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV.[1][2] The secondary structure model shows the structure prediction for the larger yeast sequences.


  1. ^ Zwieb C (1997). "The uRNA database". Nucleic Acids Res. 25 (1): 102–3. doi:10.1093/nar/25.1.102. PMC 146409. PMID 9016512. 
  2. ^ Kretzner L, Krol A, Rosbash M (1990). "Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 851–5. doi:10.1073/pnas.87.2.851. PMC 53364. PMID 2405391. 

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