Yellow nail syndrome
| Yellow nail syndrome | |
|---|---|
| Classification and external resources | |
 Yellow nail syndrome: This patient had a 20-year history of severe lymphedema of her legs; thick, ridged, yellowish, hypercurved thumbnails (top right); similarly affected, yellow-green to brown toenails (bottom right); and bilateral, chylous pleural effusions. A sample of her chylous pleural fluid is shown to the left of the radiograph. |
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| ICD-10 | L60.5 |
| OMIM | 153300 |
| MedlinePlus | 003247 |
| eMedicine | article/109403 |
Yellow nail syndrome (also known as "Primary lymphedema associated with yellow nails and pleural effusion"[1]:849) is a very rare medical syndrome that includes pleural effusions, lymphoedema and yellow dystrophic nails. Approximately 40% will also have bronchiectasis. It is also associated with chronic sinusitis and persistent coughing. It usually affects adults.[2][3]:665
Normal treatment for swelling and any respiratory problems is appropriate. Nutritional supplementation with Vitamin E in some studies has been shown to be effective in controlling nail changes.[2]
Restated, yellow nail syndrome is characterized by marked thickening and yellow to yellow-green discoloration of the nails often associated with systemic disease, most commonly lymphedema and compromised respiration.[1]:792[4]
Although it has an OMIM number, it has been suggested that it might not have a genetic link.[5]
[edit] References
- ^ a b James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ a b "Yellow nail syndrome. DermNet NZ". http://www.dermnet.org.nz/hair-nails-sweat/yellow-nails.html. Retrieved 2008-03-19.
- ^ Freedberg, et. al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0071380760.
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. 1020. ISBN 1-4160-2999-0.
- ^ Hoque SR, Mansour S, Mortimer PS (June 2007). "Yellow nail syndrome: not a genetic disorder? Eleven new cases and a review of the literature". Br. J. Dermatol. 156 (6): 1230–4. doi:10.1111/j.1365-2133.2007.07894.x. PMID 17459037. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=2007&volume=156&issue=6&spage=1230.
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