ZBP1
From Wikipedia, the free encyclopedia
| Z-DNA binding protein 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | ZBP1; C20orf183; DAI; DLM-1; DLM1 | ||||||||||||
| External IDs | OMIM: 606750 MGI: 1927449 HomoloGene: 10972 GeneCards: ZBP1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 81030 | 58203 | |||||||||||
| Ensembl | ENSG00000124256 | ENSMUSG00000027514 | |||||||||||
| UniProt | Q9H171 | Q9QY24 | |||||||||||
| RefSeq (mRNA) | NM_001160417.1 | NM_021394 | |||||||||||
| RefSeq (protein) | NP_001153889.1 | NP_067369 | |||||||||||
| Location (UCSC) | Chr 20: 56.18 – 56.2 Mb |
Chr 2: 173.03 – 173.04 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Z-DNA-binding protein 1 is a protein that in humans is encoded by the ZBP1 gene.[1][2]
[edit] Function
DLM1 encodes a Z-DNA binding protein. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling.[2]
[edit] References
- ^ Rothenburg S, Schwartz T, Koch-Nolte F, Haag F (Feb 2002). "Complex regulation of the human gene for the Z-DNA binding protein DLM-1". Nucleic Acids Res 30 (4): 993–1000. doi:10.1093/nar/30.4.993. PMC 100341. PMID 11842111. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100341.
- ^ a b "Entrez Gene: ZBP1 Z-DNA binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81030.
[edit] Further reading
- Ha SC, Van Quyen D, Hwang HY, et al. (2006). "Biochemical characterization and preliminary X-ray crystallographic study of the domains of human ZBP1 bound to left-handed Z-DNA". Biochim. Biophys. Acta 1764 (2): 320–3. doi:10.1016/j.bbapap.2005.12.012. PMID 16448869.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. USA 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Schwartz T, Behlke J, Lowenhaupt K, et al. (2001). "Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins". Nat. Struct. Biol. 8 (9): 761–5. doi:10.1038/nsb0901-761. PMID 11524677.
- Schwartz T, Rould MA, Lowenhaupt K, et al. (1999). "Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA". Science 284 (5421): 1841–5. doi:10.1126/science.284.5421.1841. PMID 10364558.
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