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Z-DNA binding protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ZBP1 ; C20orf183; DAI; DLM-1; DLM1
External IDs OMIM606750 MGI1927449 HomoloGene10972 GeneCards: ZBP1 Gene
RNA expression pattern
PBB GE ZBP1 208087 s at tn.png
More reference expression data
Species Human Mouse
Entrez 81030 58203
Ensembl ENSG00000124256 ENSMUSG00000027514
UniProt Q9H171 Q9QY24
RefSeq (mRNA) NM_001160417 NM_001139519
RefSeq (protein) NP_001153889 NP_001132991
Location (UCSC) Chr 20:
56.18 – 56.2 Mb
Chr 2:
173.21 – 173.22 Mb
PubMed search [1] [2]

Z-DNA-binding protein 1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1, is a protein that in humans is encoded by the ZBP1 gene.[1][2]

ZBP1 is also an abbreviation for chicken or rat β-actin zipcode-binding protein 1, a homolog of the human insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1) and murine CRD-BP, the proteins involved in mRNA transport (RNA-binding proteins, RBPs).


DLM1 encodes a Z-DNA binding protein. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling.[2] ZBP1 recognizes DNA in the cytoplasm as an antiviral mechanism. Viral life cycles often include steps where DNA is exposed in the cytoplasm. DNA is normally contained in the nucleus of a cell, and therefore cells use proteins like ZBP1 as an indicator of a viral infection. Once ZBP1 is activated, it increases the production of antiviral cytokines such as interferon beta.[3]

Zipcode binding protein 1 (ZBP1) was shown to regulate dendritogenesis (dendrite formation) in hippocampal neurons.[4]


  1. ^ Rothenburg S, Schwartz T, Koch-Nolte F, Haag F (Feb 2002). "Complex regulation of the human gene for the Z-DNA binding protein DLM-1". Nucleic Acids Res 30 (4): 993–1000. doi:10.1093/nar/30.4.993. PMC 100341. PMID 11842111. 
  2. ^ a b "Entrez Gene: ZBP1 Z-DNA binding protein 1". 
  3. ^ Rathinam VA, Fitzgerald KA (March 2011). "Innate immune sensing of DNA viruses". Virology 411 (2): 153–62. doi:10.1016/j.virol.2011.02.003. PMC 3070751. PMID 21334037. 
  4. ^ Perycz M, Urbanska AS, Krawczyk PS, Parobczak K, Jaworski J (April 2011). "Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons". J. Neurosci. 31 (14): 5271–85. doi:10.1523/JNEUROSCI.2387-10.2011. PMID 21471362. 

Further reading[edit]