ZBTB17

Zinc finger and BTB domain containing 17
Rendering based on PDB 2Q81.
Available structures PDB 2Q81, 3M52
Identifiers
Symbols	ZBTB17; MIZ-1; ZNF151; ZNF60; pHZ-67
External IDs	OMIM: 604084 MGI: 107410 HomoloGene: 2575 GeneCards: ZBTB17 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • zinc ion binding • metal ion binding Cellular component • intracellular • nucleus Biological process • gastrulation with mouth forming second • transcription, DNA-dependent • regulation of transcription, DNA-dependent • multicellular organismal development • ectoderm development • negative regulation of cell cycle • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7709	22642
Ensembl	ENSG00000116809	ENSMUSG00000006215
UniProt	Q13105	Q6PAT9
RefSeq (mRNA)	NM_003443	NM_009541.2
RefSeq (protein)	NP_003434	NP_033567.2
Location (UCSC)	Chr 1: 16.27 – 16.3 Mb	Chr 4: 141 – 141.02 Mb
PubMed search	[1]	[2]

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.

Interactions

ZBTB17 has been shown to interact with TOPBP1, Host cell factor C1 and Myc.

Further reading

• Lichter P, Bray P, Ried T, et al. (1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.". Genomics 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991. 
• Bray P, Lichter P, Thiesen HJ, et al. (1991). "Characterization and mapping of human genes encoding zinc finger proteins.". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9563–7. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52758. 
• Tommerup N, Vissing H (1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.". Genomics 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Wu L, Wu H, Ma L, et al. (1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA.". Mech. Dev. 65 (1–2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341. 
• Schneider A, Peukert K, Eilers M, Hänel F (1997). "Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc.". Curr. Top. Microbiol. Immunol. 224: 137–46. PMID 9308237. 
• Peukert K, Staller P, Schneider A, et al. (1997). "An alternative pathway for gene regulation by Myc.". EMBO J. 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMC 1170199. PMID 9312026. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170199. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Sui D, Wilson JE (2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.". Arch. Biochem. Biophys. 382 (2): 262–74. doi:10.1006/abbi.2000.2019. PMID 11068878. 
• Staller P, Peukert K, Kiermaier A, et al. (2001). "Repression of p15INK4b expression by Myc through association with Miz-1.". Nat. Cell Biol. 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613. 
• Ziegelbauer J, Shan B, Yager D, et al. (2001). "Transcription factor MIZ-1 is regulated via microtubule association.". Mol. Cell 8 (2): 339–49. doi:10.1016/S1097-2765(01)00313-6. PMID 11545736. 
• Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I.". J. Biol. Chem. 277 (45): 43185–93. doi:10.1074/jbc.M207635200. PMID 12193603. 
• Piluso D, Bilan P, Capone JP (2003). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1.". J. Biol. Chem. 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100. 
• Zhang H, Li Z, Viklund EK, Strömblad S (2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration.". J. Cell Biol. 158 (7): 1287–97. doi:10.1083/jcb.200207008. PMC 2173231. PMID 12356872. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173231. 
• Herold S, Wanzel M, Beuger V, et al. (2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1.". Mol. Cell 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820. 
• Wu S, Cetinkaya C, Munoz-Alonso MJ, et al. (2003). "Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.". Oncogene 22 (3): 351–60. doi:10.1038/sj.onc.1206145. PMID 12545156. 
• Bowen H, Lapham A, Phillips E, et al. (2003). "Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1.". J. Biol. Chem. 278 (38): 36017–26. doi:10.1074/jbc.M304301200. PMID 12840021. 
• Sakurai T, Itoh K, Higashitsuji H, et al. (2004). "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.". J. Biol. Chem. 279 (15): 15505–14. doi:10.1074/jbc.M310437200. PMID 14739298. 
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 

External links

• MeSH ZBTB17+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.