ZEB1

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Zinc finger E-box binding homeobox 1
Protein ZEB1 PDB 2e19.png
PDB rendering of ZEB1's homeodomain based on 2e19.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ZEB1 ; AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A
External IDs OMIM189909 MGI1344313 HomoloGene31779 GeneCards: ZEB1 Gene
RNA expression pattern
PBB GE ZEB1 210875 s at tn.png
PBB GE ZEB1 212758 s at tn.png
PBB GE ZEB1 212764 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6935 21417
Ensembl ENSG00000148516 ENSMUSG00000024238
UniProt P37275 Q64318
RefSeq (mRNA) NM_001128128 NM_011546
RefSeq (protein) NP_001121600 NP_035676
Location (UCSC) Chr 10:
31.61 – 31.82 Mb
Chr 18:
5.59 – 5.78 Mb
PubMed search [1] [2]

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[1][2][3]

TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[3][4]

Clinical significance[edit]

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[5]

References[edit]

  1. ^ Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (Dec 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828. 
  2. ^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (Feb 1992). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704. 
  3. ^ a b "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1". 
  4. ^ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704. 
  5. ^ Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Lab. Invest. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793. 

Further reading[edit]

External links[edit]