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ZFP57 zinc finger protein
Symbols ZFP57 ; C6orf40; TNDM1; ZNF698; bA145L22; bA145L22.2
External IDs OMIM612192 MGI99204 HomoloGene7603 GeneCards: ZFP57 Gene
Species Human Mouse
Entrez 346171 22715
Ensembl ENSG00000204644 ENSMUSG00000036036
UniProt Q9NU63 Q8C6P8
RefSeq (mRNA) NM_001109809 NM_001013745
RefSeq (protein) NP_001103279 NP_001013767
Location (UCSC) Chr 6:
29.64 – 29.65 Mb
Chr 17:
37 – 37.01 Mb
PubMed search [1] [2]

Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a protein that in humans is encoded by the ZFP57 gene.[1]


The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor.[1]

Clinical significance[edit]

Mutations in the ZFP57 gene may be associated with transient neonatal diabetes mellitus.[2]


  1. ^ a b "Entrez Gene: zinc finger protein 57 homolog (mouse)". 
  2. ^ Mackay DJ, Callaway JL, Marks SM et al. (August 2008). "Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57". Nat. Genet. 40 (8): 949–51. doi:10.1038/ng.187. PMID 18622393. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.