ZMPSTE24

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zinc metallopeptidase (STE24 homolog, S. cerevisiae)
Identifiers
Symbol ZMPSTE24
Entrez 10269
HUGO 12877
OMIM 606480
RefSeq NM_005857
UniProt O75844
Other data
EC number 3.4.24.84
Locus Chr. 1 p34

ZMPSTE24 is a human gene.[1][2] The protein encoded by this gene is a metallopeptidase. It is involved in the processing of lamin A.[3] Defects in the ZMPSTE24 lead to similar laminopathies as defects in lamin A, because the latter is a substrate for the former.[4]

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References[edit]

  1. ^ Tam A, Nouvet FJ, Fujimura-Kamada K, Slunt H, Sisodia SS, Michaelis S (August 1998). "Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing". J. Cell Biol. 142 (3): 635–49. doi:10.1083/jcb.142.3.635. PMC 2148179. PMID 9700155. 
  2. ^ Freije JM, Blay P, Pendás AM, Cadiñanos J, Crespo P, López-Otín C (June 1999). "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins". Genomics 58 (3): 270–80. doi:10.1006/geno.1999.5834. PMID 10373325. 
  3. ^ Young SG, Fong LG, Michaelis S (December 2005). "Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis". J. Lipid Res. 46 (12): 2531–58. doi:10.1194/jlr.R500011-JLR200. PMID 16207929. 
  4. ^ Varela I, Cadiñanos J, Pendás AM, Gutiérrez-Fernández A, Folgueras AR, Sánchez LM, Zhou Z, Rodríguez FJ, Stewart CL, Vega JA, Tryggvason K, Freije JM, López-Otín C (September 2005). "Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation". Nature 437 (7058): 564–8. doi:10.1038/nature04019. PMID 16079796. 

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