ZMYND11

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Zinc finger, MYND-type containing 11
Identifiers
Symbols ZMYND11 ; BRAM1; BS69
External IDs OMIM608668 MGI1913755 HomoloGene4828 GeneCards: ZMYND11 Gene
RNA expression pattern
PBB GE ZMYND11 202136 at tn.png
PBB GE ZMYND11 202137 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10771 66505
Ensembl ENSG00000015171 ENSMUSG00000021156
UniProt Q15326 Q8R5C8
RefSeq (mRNA) NM_001202464 NM_001199141
RefSeq (protein) NP_001189393 NP_001186070
Location (UCSC) Chr 10:
0.23 – 0.3 Mb
Chr 13:
9.68 – 9.77 Mb
PubMed search [1] [2]

Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene.[1][2][3]

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Interactions[edit]

ZMYND11 has been shown to interact with ETS2,[4] BMPR1A,[5] MAP3K7IP1[5] and C11orf30.[6]

References[edit]

  1. ^ Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R (Aug 1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation". EMBO J 14 (13): 3159–69. PMC 394377. PMID 7621829. 
  2. ^ Masselink H, Bernards R (Apr 2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313. 
  3. ^ a b "Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11". 
  4. ^ Wei, Guo; Schaffner Alicia Erbe, Baker Kimberly M, Mansky Kim C, Ostrowski Michael C (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Res. (Greece) 23 (3A): 2173–8. ISSN 0250-7005. PMID 12894593. 
  5. ^ a b Kurozumi, K; Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes Cells (ENGLAND) 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. ISSN 1356-9597. PMID 9663660. 
  6. ^ Hughes-Davies, Luke; Huntsman David, Ruas Margarida, Fuks Francois, Bye Jacqueline, Chin Suet-Feung, Milner Jonathon, Brown Lindsay A, Hsu Forrest, Gilks Blake, Nielsen Torsten, Schulzer Michael, Chia Stephen, Ragaz Joseph, Cahn Anthony, Linger Lori, Ozdag Hilal, Cattaneo Elena, Jordanova E S, Schuuring Edward, Yu David S, Venkitaraman Ashok, Ponder Bruce, Doherty Aidan, Aparicio Samuel, Bentley David, Theillet Charles, Ponting Chris P, Caldas Carlos, Kouzarides Tony (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell (United States) 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. ISSN 0092-8674. PMID 14651845. 

Further reading[edit]