ZNF10

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Zinc finger protein 10
Identifiers
Symbols ZNF10 ; KOX1
External IDs OMIM194538 HomoloGene130674 GeneCards: ZNF10 Gene
RNA expression pattern
PBB GE ZNF10 216350 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7556 n/a
Ensembl ENSG00000256223 n/a
UniProt P21506 n/a
RefSeq (mRNA) NM_015394 n/a
RefSeq (protein) NP_056209 n/a
Location (UCSC) Chr 12:
133.71 – 133.74 Mb
n/a
PubMed search [1] n/a

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.[1][2][3]

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.[3]

Interactions[edit]

ZNF10 has been shown to interact with TRIM28.[4][5]

References[edit]

  1. ^ Abrink M, Aveskogh M, Hellman L (March 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130. 
  2. ^ Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seite P, Thiesen HJ, Berger R (January 1994). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Hum Genet 92 (6): 583–7. doi:10.1007/BF00420943. PMID 8262519. 
  3. ^ a b "Entrez Gene: ZNF10 zinc finger protein 10". 
  4. ^ Moosmann, P; Georgiev O; Le Douarin B; Bourquin J P; Schaffner W (December 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Res. (ENGLAND) 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. ISSN 0305-1048. PMC 146346. PMID 9016654. 
  5. ^ Peng, H; Begg G E; Harper S L; Friedman J R; Speicher D W; Rauscher F J (June 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". J. Biol. Chem. (UNITED STATES) 275 (24): 18000–10. doi:10.1074/jbc.M001499200. ISSN 0021-9258. PMID 10748030. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.