ZNF202

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Zinc finger protein 202
Identifiers
Symbols ZNF202 ; ZKSCAN10; ZSCAN42
External IDs OMIM603430 MGI1933401 HomoloGene68317 GeneCards: ZNF202 Gene
RNA expression pattern
PBB GE ZNF202 204327 s at tn.png
PBB GE ZNF202 204329 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7753 80902
Ensembl ENSG00000166261 ENSMUSG00000025602
UniProt O95125 E9Q2D3
RefSeq (mRNA) NM_003455 NM_030713
RefSeq (protein) NP_003446 NP_109638
Location (UCSC) Chr 11:
123.59 – 123.61 Mb
Chr 9:
40.19 – 40.21 Mb
PubMed search [1] [2]

Zinc finger protein 202 is a transcription factor first associated with breast cancer. It is a protein that, in humans, is encoded by the ZNF202 gene.[1][2]

Clinical significance[edit]

Variants of this protein have been discovered to be strongly associated with coronary heart disease and atherosclerosis.

References[edit]

  1. ^ Monaco C, Helmer Citterich M, Caprini E, Vorechovsky I, Russo G, Croce CM et al. (Sep 1998). "Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins". Genomics 52 (3): 358–62. doi:10.1006/geno.1998.5419. PMID 9790754. 
  2. ^ "Entrez Gene: ZNF202 zinc finger protein 202". 

Further reading[edit]

  • Iuchi, Shiro; Kuldell, Natalie (2005). Zinc finger proteins: from atomic contact to cellular function. Molecular biology intelligence unit. シュプリンガー・ジャパン株式会社. p. 161. ISBN 0-306-48229-0. 
  • Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V et al. (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. Journal International Du Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. 
  • Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q et al. (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874. 
  • Wagner S, Hess MA, Ormonde-Hanson P, Malandro J, Hu H, Chen M et al. (May 2000). "A broad role for the zinc finger protein ZNF202 in human lipid metabolism". The Journal of Biological Chemistry 275 (21): 15685–90. doi:10.1074/jbc.M910152199. PMID 10748193. 
  • Porsch-Ozcurumez M, Langmann T, Heimerl S, Borsukova H, Kaminski WE, Drobnik W et al. (Apr 2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". The Journal of Biological Chemistry 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031. 
  • Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Steffensen R, Schnohr P, Tybjaerg-Hansen A (Sep 2006). "Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study". Atherosclerosis 188 (1): 43–50. doi:10.1016/j.atherosclerosis.2005.10.014. PMID 16289551. 
  • Stene MC, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A (May 2006). "Zinc Finger Protein 202, genetic variation, and HDL cholesterol in the general population". Journal of Lipid Research 47 (5): 944–52. doi:10.1194/jlr.M500521-JLR200. PMID 16467280. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.