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Zinc finger protein 346
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ZNF346 ; JAZ; Zfp346
External IDs OMIM605308 MGI1349417 HomoloGene8073 GeneCards: ZNF346 Gene
Species Human Mouse
Entrez 23567 26919
Ensembl ENSG00000113761 ENSMUSG00000021481
UniProt Q9UL40 Q9R0B7
RefSeq (mRNA) NM_012279 NM_012017
RefSeq (protein) NP_036411 NP_036147
Location (UCSC) Chr 5:
176.45 – 176.51 Mb
Chr 13:
55.11 – 55.13 Mb
PubMed search [1] [2]

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.[1][2]

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival.[2]


  1. ^ Yang M, May WS, Ito T (Nov 1999). "JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization". J Biol Chem 274 (39): 27399–406. doi:10.1074/jbc.274.39.27399. PMID 10488071. 
  2. ^ a b "Entrez Gene: ZNF346 zinc finger protein 346". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.