ZNF423

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Zinc finger protein 423
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ZNF423 ; Ebfaz; JBTS19; NPHP14; OAZ; Roaz; ZFP423; Zfp104
External IDs OMIM604557 MGI1891217 HomoloGene9010 GeneCards: ZNF423 Gene
RNA expression pattern
PBB GE ZNF423 214761 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23090 94187
Ensembl ENSG00000102935 ENSMUSG00000045333
UniProt Q2M1K9 Q80TS5
RefSeq (mRNA) NM_001271620 NM_033327
RefSeq (protein) NP_001258549 NP_201584
Location (UCSC) Chr 16:
49.52 – 49.89 Mb
Chr 8:
87.66 – 87.96 Mb
PubMed search [1] [2]

Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.[1][2][3]

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.[3]

Interactions[edit]

ZNF423 has been shown to interact with EBF1[4] and PARP1.[5]

References[edit]

  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
  2. ^ Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massague J (Feb 2000). "OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways". Cell 100 (2): 229–40. doi:10.1016/S0092-8674(00)81561-5. PMID 10660046. 
  3. ^ a b "Entrez Gene: ZNF423 zinc finger protein 423". 
  4. ^ Tsai, R Y; Reed R R (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. (UNITED STATES) 17 (11): 4159–69. ISSN 0270-6474. PMID 9151733. 
  5. ^ Ku, Man-ching; Stewart Shavonne, Hata Akiko (Nov 2003). "Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes". Biochem. Biophys. Res. Commun. (United States) 311 (3): 702–7. doi:10.1016/j.bbrc.2003.10.053. ISSN 0006-291X. PMID 14623329. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.