Hamilton, a 6'11" center played high school basketball at Floral Park, New York's Sewanhaka High School. Hamilton played college basketball at St. John's University, where he was a part of the same recruiting class as SI cover boy Felipe López.
Hamilton began his NBA career in the 2000–01 NBA season with the Los Angeles Clippers. He had previously played with the Dallas Mavericks in the NBA pre-season in 1999, but he did not play in any official NBA games with Dallas. He has also played for the Denver Nuggets, the Toronto Raptors, the Philadelphia 76ers, the Milwaukee Bucks, and the Cleveland Cavaliers. He was signed on October 1, 2006, by the Portland Trail Blazers, but after the pre-season he was waived on October 25, 2006, without playing any regular season games with the club.
In February 2007, he joined Śląsk Wrocław. In the summer of 2007, he moved to Russia and signed with Enisey Krasnoyarsk. In 2008, he joined Spartak Primorje. In 2010, he joined Polytekhnika-Halychyna Lviv. In 2012, he joined Larre Borges of Uruguay.
- " HIGH SCHOOL BASKETBALL; New York Area Is Teeming With Talent", The New York Times, December 12, 1993. Accessed December 27, 2007. "ZENDON HAMILTON of Sewanhaka, is rated the best senior big man in the nation by various prep school magazines, including Street & Smith."
- Zendon Hamilton. Latinbasket
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