Makrypoulia graduated from Vasilis Diamantopoulos' Drama School in 1994, while she has also attended acting classes at Theatro ton Allagon. Then she started appearing on television and has participated in various shows and commercials for the last 14 years. She also has worked in various television productions. Makrypoulia appeared in the hit series Para Pente, with her performance as a naive village girl in the series. Zeta and actor/scriptwriter Giorgos Kapoutzidis will be part of this year's Eurovision's commentators during the 51st Eurovision Song Contest in Athens. Aside from television productions Zeta has also appeared on stage, debuting for the first time in 2005 in the theatrical play "Sesouar gia Dolofonous". For the past seven years, she has also been working as a radio DJ for well-known radio stations, including Ciao FM and Sfera 102.2. Recently she starred in Wog Boy 2: Kings of Mykonos alongside Nick Giannopoulos and Vince Colosimo as Zoe, Giannopoulos' love interest. From 2010 to 2012 she presented the Greek version of Dancing With The Stars.