Zicronapine

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Zicronapine
Zicronapine.svg
Systematic (IUPAC) name
4-[(1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl]-1,2,2-trimethylpiperazine
Clinical data
Legal status
?
Identifiers
CAS number 170381-16-5
ATC code ?
PubChem CID 11465618
ChemSpider 9640456
KEGG D10329 YesY
Chemical data
Formula C22H27ClN2 
Mol. mass 354.9 g/mol

Zicronapine (zye-KRON-a-peen, previously known as Lu 31-130) is an atypical antipsychotic medication currently under development by H. Lundbeck A/S. In phase II studies zicronapine did show statistical significant separation from placebo and very convincing efficacy and safety data when compared to olanzapine.[1]

Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors.[2]

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