Zinc-activated ion channel

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Zinc activated ligand-gated ion channel
External IDs OMIM610935 HomoloGene52296 IUPHAR: ZAC ChEMBL: 1628479 GeneCards: ZACN Gene
Species Human Mouse
Entrez 353174 n/a
Ensembl ENSG00000186919 n/a
UniProt Q401N2 n/a
RefSeq (mRNA) NM_180990 n/a
RefSeq (protein) NP_851321 n/a
Location (UCSC) Chr 17:
74.07 – 74.08 Mb
PubMed search [1] n/a

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.[1]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.[1][2] The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.[1]


  1. ^ a b c Davies PA; Wang W; Hales TG; Kirkness EF (2003). "A novel class of ligand-gated ion channel is activated by Zn2+". J Biol. Chem. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728. 
  2. ^ Houtani T; Munemoto Y; Kase M; Sakuma S; Tsutsumi T; Sugimoto T (2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochem Biophys Res Commun 335 (2): 227–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.