Zinc finger FYVE domain-containing protein 9

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Zinc finger, FYVE domain containing 9
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603755 MGI2652838 HomoloGene3527 GeneCards: ZFYVE9 Gene
Species Human Mouse
Entrez 9372 230597
Ensembl ENSG00000157077 ENSMUSG00000034557
UniProt O95405 A0S860
RefSeq (mRNA) NM_004799 NM_183300
RefSeq (protein) NP_004790 NP_899123
Location (UCSC) Chr 1:
52.61 – 52.81 Mb
Chr 4:
108.64 – 108.78 Mb
PubMed search [1] [2]

Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ZFYVE9 gene.[1] SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.[2] It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.


  1. ^ Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (December 1998). "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor". Cell 95 (6): 779–791. doi:10.1016/S0092-8674(00)81701-8. PMID 9865696. 
  2. ^ Lin HK, Bergmann S, Pandolfi PP (September 2004). "Cytoplasmic PML function in TGF-beta signalling". Nature 431 (7005): 205–211. doi:10.1038/nature02783. PMID 15356634.