Zinc finger and BTB domain-containing protein 16

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Zinc finger and BTB domain containing 16
Protein ZBTB16 PDB 1buo.png
PDB rendering based on 1buo.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ZBTB16 ; PLZF; ZNF145
External IDs OMIM176797 MGI103222 HomoloGene21214 GeneCards: ZBTB16 Gene
RNA expression pattern
PBB GE ZBTB16 205883 at tn.png
More reference expression data
Species Human Mouse
Entrez 7704 235320
Ensembl ENSG00000109906 ENSMUSG00000066687
UniProt Q05516 A3KMN0
RefSeq (mRNA) NM_001018011 NM_001033324
RefSeq (protein) NP_001018011 NP_001028496
Location (UCSC) Chr 11:
113.93 – 114.12 Mb
Chr 9:
48.65 – 48.84 Mb
PubMed search [1] [2]

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.


This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)[1] and physiological roles have been identified in mouse Natural Killer T cells[2][3] and gamma-delta T cells.[4] Alternate transcriptional splice variants have been characterized in human.[5][6]


Zinc finger and BTB domain-containing protein 16 has been shown to interact with:

See also[edit]


  1. ^ Chen Z, Brand N, Chen A, Chen S, Tong J, Wang Z et al. (1993). "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". The EMBO Journal 12 (3): 1161–7. PMC 413318. PMID 8384553. 
  2. ^ Kovalovsky D, Uche O, Eladad S, Hobbs R, Yi W, Alonzo E, Chua K, Eidson M et al. (2008). "The BTB-zinc finger transcriptional regulator, PLZF, controls the development of iNKT cell effector functions". Nature Immunology 9 (9): 1055–64. doi:10.1038/ni.1641. PMC 2662733. PMID 18660811. 
  3. ^ Savage A, Constantinides M, Han J, Picard D, Martin E, Li B et al. (2008). "The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage". Immunity 29 (3): 391–403. doi:10.1016/j.immuni.2008.07.011. PMC 2613001. PMID 18703361. 
  4. ^ Kreslavsky T, Savage A, Hobbs R, Gounari F, Bronson R, Pereira P et al. (2009). "TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity". Proceedings of the National Academy of Sciences of the United States of America 106 (30): 12453–8. doi:10.1073/pnas.0903895106. PMC 2718370. PMID 19617548. 
  5. ^ Zhang T, Xiong H, Kan L, Zhang C, Jiao X, Fu G, Zhang Q, Lu L et al. (1999). "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proceedings of the National Academy of Sciences of the United States of America 96 (20): 11422–7. doi:10.1073/pnas.96.20.11422. PMC 18049. PMID 10500192. 
  6. ^ "ZBTB16 zinc finger and BTB domain containing 16". Entrez. 4 October 2009. Retrieved 10 October 2009. 
  7. ^ Senbonmatsu T, Saito T, Landon E, Watanabe O, Price E, Roberts R, Imboden H, Fitzgerald T et al. "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy". EMBO J. 22 (24): 6471–82. doi:10.1093/emboj/cdg637. PMC 291832. PMID 14657020. 
  8. ^ Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M et al. "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene 19 (54): 6240–50. doi:10.1038/sj.onc.1203976. PMID 11175338. 
  9. ^ Barna M, Merghoub T, Costoya J, Ruggero D, Branford M, Bergia A et al. "Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling". Dev. Cell 3 (4): 499–510. PMID 12408802. 
  10. ^ a b Ward J, McConnell M, Carlile G, Pandolfi P, Licht J, Freedman L. "The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor". Blood 98 (12): 3290–300. PMID 11719366. 
  11. ^ Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D et al. "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8. PMID 12460926. 
  12. ^ McLoughlin P, Ehler E, Carlile G, Licht J, Schäfer B. "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein". J. Biol. Chem. 277 (40): 37045–53. doi:10.1074/jbc.M203336200. PMID 12145280. 
  13. ^ Labbaye C, Quaranta M, Pagliuca A, Militi S, Licht J, Testa U et al. "PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein". Oncogene 21 (43): 6669–79. doi:10.1038/sj.onc.1205884. PMID 12242665. 
  14. ^ Tsuzuki S, Enver T. "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood 99 (9): 3404–10. PMID 11964310. 
  15. ^ a b c d Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard L, Mishal Z et al. "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene 23 (54): 8777–84. doi:10.1038/sj.onc.1208128. PMID 15467736. 
  16. ^ a b c David G, Alland L, Hong S, Wong C, DePinho R, Dejean A. "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120. 
  17. ^ a b c Wong C, Privalsky M. "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. 273 (42): 27695–702. PMID 9765306. 
  18. ^ a b Lemercier C, Brocard M, Puvion-Dutilleul F, Kao H, Albagli O, Khochbin S. "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873. 
  19. ^ Nanba D, Mammoto A, Hashimoto K, Higashiyama S. "Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF". J. Cell Biol. 163 (3): 489–502. doi:10.1083/jcb.200303017. PMC 2173632. PMID 14597771. 
  20. ^ Nanba D, Toki F, Higashiyama S. "Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF". Biochem. Biophys. Res. Commun. 320 (2): 376–82. doi:10.1016/j.bbrc.2004.05.176. PMID 15219838. 
  21. ^ Takahashi S, McConnell M, Harigae H, Kaku M, Sasaki T, Melnick A et al. "The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT". Blood 103 (12): 4650–8. doi:10.1182/blood-2003-08-2759. PMID 14982881. 
  22. ^ Hong S, David G, Wong C, Dejean A, Privalsky M. "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9028–33. PMC 23013. PMID 9256429. 
  23. ^ Koken M, Reid A, Quignon F, Chelbi-Alix M, Davies J, Kabarowski J, Zhu J, Dong S et al. "Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10255–60. PMC 23349. PMID 9294197. 
  24. ^ Melnick A, Westendorf J, Polinger A, Carlile G, Arai S, Ball H et al. "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6): 2075–86. PMC 110824. PMID 10688654. 
  25. ^ Melnick A, Carlile G, McConnell M, Polinger A, Hiebert S, Licht J. "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood 96 (12): 3939–47. PMID 11090081. 
  26. ^ Martin P, Delmotte M, Formstecher P, Lefebvre P. "PLZF is a negative regulator of retinoic acid receptor transcriptional activity". Nucl. Recept. 1 (1): 6. doi:10.1186/1478-1336-1-6. PMC 212040. PMID 14521715. 
  27. ^ Hoatlin M, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N et al. "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood 94 (11): 3737–47. PMID 10572087. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.