In her solo performances and recordings Keating uses live electronic sampling and repetition in order to layer the sound of her cello, creating rhythmically dense musical structures. As of 29 October 2012[update], Keating uses Ableton Live and SooperLooper software along with Keith McMillen Instruments' SoftStep Foot Controller. Her self-produced album One Cello x 16: Natoma was four times #1 on the iTunes classical charts and "Into the Trees" spent 47 weeks on the Billboard classical chart, peaking at #7. She is the recipient of a 2009 Performing Arts grant from the Creative Capital Foundation.
Keating's songs have been featured in various commercials, TV shows, films, and dance performances including CBS's Elementary, NBC's Crisis, So You Think You Can Dance, HBO's Teen Wolf, Dateline, Have You Heard from Johannesburg, The Day Carl Sandburg Died, Alice Walker: Beauty in Truth, The Retrieval.
In March 2010, Keating announced via her website that she was expecting her first child with her husband Jeff Rusch in May. She gave birth to a son, Alex, on May 12, 2010.
Her husband Jeff Rusch was diagnosed with stage 4 cancers in May 2014, and was admitted to the hospital for emergency treatment. Days later, Keating and Rusch received a letter denying coverage for this hospital stay by their insurance company, Anthem Blue Cross. After local media publicized the story, Anthem Blue Cross reversed its decision, telling Keating in a phone call that the hospital stay will be covered. 
^Zoë Keating (2010-03-09). "Zoe's Incredibly Interesting Blog: Expanding". Blog.zoekeating.com. Retrieved 2013-09-01. "However, I doubt you will find the poster the most interesting thing about this photo .... http://www.zoekeating.com/blog/uploaded_images/P2211062-788701.jpg ahem. Yes, its true! We're expecting a baby in MAY! So, if you see me over the next couple months, please don't think my latest hippo-look is just because I've gone all crazy with the chocolate ice cream (although I admit I have felt compelled to eat a fair amount of it over the last few months)."