Zofenopril

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Zofenopril
Zofenopril.png
Systematic (IUPAC) name
(2S,4R)-1-((S)-3-(benzoylthio)-2-methylpropanoyl)-4-(phenylthio)pyrrolidine-2-carboxylic acid
Clinical data
AHFS/Drugs.com International Drug Names
Legal status ?
Routes Oral
Identifiers
CAS number 81872-10-8 YesY
ATC code C09AA15
PubChem CID 92400
ChemSpider 83422 N
UNII 290ZY759PI N
KEGG D08688 YesY
ChEBI CHEBI:78539 N
ChEMBL CHEMBL331378 N
Chemical data
Formula C22H23NO4S2 
Mol. mass 429.552 g/mol
 N (what is this?)  (verify)

Zofenopril (also known as Zofenoprilum [Latin]) is an angiotensin converting enzyme (ACE) inhibitor with cardioprotective properties indicated for the treatment of hypertension.[1]

In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with less adverse effects.[2][3]

References[edit]

  1. ^ Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs 7 (1): 17–24. doi:10.2165/00129784-200707010-00002. PMID 17355163. 
  2. ^ Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl 2: 25–30. PMID 18046976. 
  3. ^ Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl 2: 13–8. PMID 18046974.