Princess Zofia Czartoryska (15 September 1778 – 27 February 1837) was a Polish noble lady. She was the youngest daughter of Countess Izabela Czartoryska née Fleming and her husband Prince Adam Kazimierz Czartoryski, though her father may actually have been Count Franciszek Ksawery Branicki.
She married Stanisław Kostka Zamoyski on 20 May 1798, at Puławy.
She is an ancestor of Queen Mathilde of Belgium. Her daughter Jadwiga Klementyna Zamoyska and Prince Leon Sapieha-Kodenski's great-great-granddaughter, Princess Zofia Sapieha-Kodenska, is Queen Mathilde's maternal grandmother, who died in a car accident with the princess's sister, Marie-Alix d'Udekem d'Acoz. He is 6th-generation ancestor to Queen Mathilde.