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Chemical structure of zucapsaicin
Systematic (IUPAC) name
Clinical data
Trade names Civanex
Legal status ?
Routes Topical
CAS number 25775-90-0
ATC code M02AB02
PubChem CID 1548942
ChemSpider 1265956
UNII 15OX67P384
Synonyms Civamide; (Z)-Capsaicin; cis-Capsaicin
Chemical data
Formula C18H27NO3 
Mol. mass 305.41188 g/mol

Zucapsaicin (Civanex) is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three times daily for a maximum of three months. It reduces pain, and improves articular functions. It is the cis-isomer of capsaicin. Civamide, manufactured by Winston Pharmaceuticals, is produced in formulations for oral, nasal, and topical use (patch and cream).[1]

Zucapsaicin has been tested for treatment of a variety of conditions associated with ongoing nerve pain. This includes herpes simplex infections; cluster headaches and migraine; and knee osteoarthritis.[2]


  1. ^ Winston Pharmaceuticals website http://www.winstonlabs.com/productdevelopment/civamide.asp
  2. ^ Zucapsaicin information from the National Library of Medicine http://druginfo.nlm.nih.gov/drugportal