Glassy cell carcinoma of the cervix
| Glassy cell carcinoma of the cervix | |
|---|---|
| Other names | Glassy cell carcinoma |
 | |
| Micrograph of a glassy cell carcinoma of the cervix. H&E stain. | |
| Specialty | Oncology  |
Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix.[1] The tumour gets its name from its microscopic appearance; its cytoplasm has a glass-like appearance.
Signs and symptoms[edit]
The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.[citation needed]
Cause[edit]
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Diagnosis[edit]
The diagnosis is based on tissue examination, e.g. biopsy.[citation needed]
Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated with an inflammatory infiltrate abundant in eosinophils and very mitotically active. PAS staining highlights the plasma membrane.[2]
Treatment[edit]
The treatment is dependent on the stage. Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and chemotherapy.[2]
See also[edit]
Additional images[edit]
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High mag.
References[edit]
- ^ Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix". Journal of Obstetrics and Gynaecology Research. 35 (3): 584–7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406. S2CID 23501330.
- ^ a b Deshpande, AH.; Kotwal, MN.; Bobhate, SK. (2004). "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature". Indian J Cancer. 41 (2): 92–5. doi:10.4103/0019-509X.12353. hdl:1807/2939. PMID 15318016. S2CID 8377065.
Further reading[edit]
- Greer, Benjamin E.; Koh, Wui-Jin; Abu-Rustum, Nadeem; Bookman, Michael A.; Bristow, Robert E.; Campos, Susana M.; Cho, Kathleen R.; Copeland, Larry; Crispens, Marta Ann; Eifel, Patricia J.; Huh, Warner K.; Jaggernauth, Wainwright; Kapp, Daniel S.; Kavanagh, John J.; Lurain, John R.; Morgan, Mark; Morgan, Robert J.; Powell, C. Bethan; Remmenga, Steven W.; Reynolds, R. Kevin; Secord, Angeles Alvarez; Small, William; Teng, Nelson (1 May 2009). "Uterine Neoplasms". Journal of the National Comprehensive Cancer Network. 7 (5): 498–531. doi:10.6004/jnccn.2009.0035. ISSN 1540-1405. PMID 19460278. Retrieved 19 July 2017.