Alphacetylmethadol: Difference between revisions
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'''Alphacetylmethadol''' ([[International Nonproprietary Name|INN]]), or '''α-acetylmethadol''' ('''AAM'''), is a [[Chemical synthesis|synthetic]] [[opioid]] [[analgesic]].<ref name="pmid12373424">{{cite journal |vauthors=Newman JL, Vann RE, May EL, Beardsley PM | title = Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats | journal = Psychopharmacology | volume = 164 | issue = 1 | pages = 108–14 |date=October 2002 | pmid = 12373424 | doi = 10.1007/s00213-002-1198-8 | s2cid = 19815273 }}</ref> Its [[levorotary]] [[enantiomer]], [[levacetylmethadol]], is an FDA-approved treatment for [[opioid addiction]].<ref name="pmid12373424" /> Alphacetylmethadol is very similar in structure to [[methadone]], a widely prescribed treatment for opioid addiction. In the [[United States]], it is a [[List of Schedule I drugs (US)|Schedule I controlled substance]] under the [[Controlled Substances Act]] (presumably because it was never marketed in the US, as is the case with other common opiate/opioid medications such as [[heroin]] and [[prodine]]),<ref>{{uscsub|21|812|b|1}}</ref> with an ACSCN of 9603 and a 2013 annual manufacturing quota of 2 grammes.{{cn|date=October 2023}} |
'''Alphacetylmethadol''' ([[International Nonproprietary Name|INN]]), or '''α-acetylmethadol''' ('''AAM'''), is a [[Chemical synthesis|synthetic]] [[opioid]] [[analgesic]].<ref name="pmid12373424">{{cite journal |vauthors=Newman JL, Vann RE, May EL, Beardsley PM | title = Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats | journal = Psychopharmacology | volume = 164 | issue = 1 | pages = 108–14 |date=October 2002 | pmid = 12373424 | doi = 10.1007/s00213-002-1198-8 | s2cid = 19815273 }}</ref> Its [[levorotary]] [[enantiomer]], [[levacetylmethadol]], is an FDA-approved treatment for [[opioid addiction]]; however as of 2003 it is no longer used in the United States for this purpose.<ref name="pmid12373424" /> Alphacetylmethadol is very similar in structure to [[methadone]], a widely prescribed treatment for opioid addiction. In the [[United States]], it is a [[List of Schedule I drugs (US)|Schedule I controlled substance]] under the [[Controlled Substances Act]] (presumably because it was never marketed in the US, as is the case with other common opiate/opioid medications such as [[heroin]] and [[prodine]]),<ref>{{uscsub|21|812|b|1}}</ref> with an ACSCN of 9603 and a 2013 annual manufacturing quota of 2 grammes.{{cn|date=October 2023}} |
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== See also == |
== See also == |
Latest revision as of 14:35, 15 November 2023
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Formula | C23H31NO2 |
Molar mass | 353.506 g·mol−1 |
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Alphacetylmethadol (INN), or α-acetylmethadol (AAM), is a synthetic opioid analgesic.[3] Its levorotary enantiomer, levacetylmethadol, is an FDA-approved treatment for opioid addiction; however as of 2003 it is no longer used in the United States for this purpose.[3] Alphacetylmethadol is very similar in structure to methadone, a widely prescribed treatment for opioid addiction. In the United States, it is a Schedule I controlled substance under the Controlled Substances Act (presumably because it was never marketed in the US, as is the case with other common opiate/opioid medications such as heroin and prodine),[4] with an ACSCN of 9603 and a 2013 annual manufacturing quota of 2 grammes.[citation needed]
See also
[edit]References
[edit]- ^ Richard Lawrence Miller (30 December 2002). The Encyclopedia of Addictive Drugs. Greenwood Publishing Group. p. 222. ISBN 978-0-313-31807-8. Retrieved 15 May 2012.
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
- ^ a b Newman JL, Vann RE, May EL, Beardsley PM (October 2002). "Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats". Psychopharmacology. 164 (1): 108–14. doi:10.1007/s00213-002-1198-8. PMID 12373424. S2CID 19815273.
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