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Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: ChEMBL.
m →‎top: task, replaced: Naunyn Schmiedebergs → Naunyn-Schmiedeberg's
 
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{{chembox
{{chembox
| verifiedrevid = 413864685
|ImageFile=Amthamine.svg
| ImageFile=Amthamine.svg
|ImageSize=
| ImageSize=
|IUPACName=5-(2-aminoethyl)-4-methyl-1,3-thiazol-2-amine
|OtherNames=5-(2-aminoethyl)-4-methyl-2-thiazolamine</br>2-amino-5-(2-aminoethyl)-4-methylthiazole
| IUPACName=5-(2-Aminoethyl)-4-methyl-1,3-thiazol-2-amine
| OtherNames=5-(2-Aminoethyl)-4-methyl-2-thiazolamine<br />2-Amino-5-(2-aminoethyl)-4-methylthiazole
|Section1={{Chembox Identifiers
|Section1={{Chembox Identifiers
| ChemSpiderID = 112538
| IUPHAR_ligand = 4025
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 112538
| InChI = 1/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
| InChI = 1/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
| InChIKey = LHVRFUVVRXGZPV-UHFFFAOYAV
| InChIKey = LHVRFUVVRXGZPV-UHFFFAOYAV
| SMILES1 = n1c(c(sc1N)CCN)C
| SMILES1 = n1c(c(sc1N)CCN)C
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 293762
| ChEMBL = 293762
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
| StdInChI = 1S/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = LHVRFUVVRXGZPV-UHFFFAOYSA-N
| StdInChIKey = LHVRFUVVRXGZPV-UHFFFAOYSA-N
| CASNo=142437-67-0
| CASNo=142437-67-0
| CASNo_Ref = {{cascite|correct|CAS}}
⚫
| PubChem=126688
| UNII_Ref = {{fdacite|correct|FDA}}
⚫
| SMILES=CC1=C(SC(=N1)N)CCN
| UNII = N4ZJ2D98HM
⚫
| PubChem=126688
⚫
| SMILES=CC1=C(SC(=N1)N)CCN
}}
}}
|Section2={{Chembox Properties
|Section2={{Chembox Properties
| Formula=C<sub>6</sub>H<sub>11</sub>N<sub>3</sub>S
| Formula=C<sub>6</sub>H<sub>11</sub>N<sub>3</sub>S
| MolarMass=157.236 g/mol
| MolarMass=157.236 g/mol
| Appearance=
| Appearance=
| Density=
| Density=
| MeltingPt=
| MeltingPt=
| BoilingPt=
| BoilingPt=
| Solubility=
| Solubility=
}}
}}
|Section3={{Chembox Hazards
|Section3={{Chembox Hazards
| MainHazards=
| MainHazards=
| FlashPt=
| FlashPt=
| AutoignitionPt =
| Autoignition=
}}
}}
}}
}}
'''Amthamine''' is a [[histamine agonist]] selective for the [[Histamine H2 receptor|H<sub>2</sub>]] subtype.<ref>Eriks JC, van der Goot H, Sterk GJ, Timmerman H. Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles. ''Journal of Medicinal Chemistry''. 1992 Aug 21;35(17):3239-46. PMID 1507209</ref> It has been used ''[[in vitro]]'' and ''[[in vivo]]'' to study [[gastric secretion]],<ref>{{cite journal |doi=10.1007/BF00168540 |author=Coruzzi G, Timmerman H, Adami M, Bertaccini G |title=The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion |journal=Naunyn Schmiedebergs Arch Pharmacol |volume=348 |issue=1 |pages=77–81 |year=1993 |month=July |pmid=8377843}}</ref> as well as other functions of the H<sub>2</sub> receptor.<ref>Ezeamuzie CI, Philips E. Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation. ''British Journal of Pharmacology''. 2000 Oct;131(3):482-8. PMID 11015298</ref><ref>Fernandez N, Monczor F, Baldi A, Davio C, Shayo C. Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization. ''Molecular Pharmacology''. 2008 Oct;74(4):1109-18. PMID 18617631</ref><ref>Threlfell S, Exley R, Cragg SJ, Greenfield SA. Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra. ''Journal of Neurochemistry''. 2008 Nov;107(3):745-55. PMID 18761715</ref>
'''Amthamine''' is a [[histamine agonist]] selective for the [[Histamine H2 receptor|H<sub>2</sub>]] subtype.<ref>{{cite journal|pmid=1507209|year=1992|last1=Eriks|first1=J. C|title=Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles|journal=Journal of Medicinal Chemistry|volume=35|issue=17|pages=3239–46|last2=Van Der Goot|first2=H|last3=Sterk|first3=G. J|last4=Timmerman|first4=H|doi=10.1021/jm00095a021}}</ref> It has been used ''[[in vitro]]'' and ''[[in vivo]]'' to study [[gastric secretion]],<ref>{{cite journal |doi=10.1007/BF00168540 |vauthors =Coruzzi G, Timmerman H, Adami M, Bertaccini G |title=The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion |journal=Naunyn-Schmiedeberg's Arch Pharmacol |volume=348 |issue=1 |pages=77–81 |date=July 1993 |pmid=8377843|s2cid =20132912 }}</ref> as well as other functions of the H<sub>2</sub> receptor.<ref>{{cite journal|pmid=11015298|pmc=1572337|year=2000|last1=Ezeamuzie|first1=C. I|title=Histamine H(2) receptors mediate the inhibitory effect of histamine on human eosinophil degranulation|journal=British Journal of Pharmacology|volume=131|issue=3|pages=482–8|last2=Philips|first2=E|doi=10.1038/sj.bjp.0703556}}</ref><ref>{{cite journal|pmid=18617631|year=2008|last1=Fernandez|first1=N|title=Histamine H2 receptor trafficking: Role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization|journal=Molecular Pharmacology|volume=74|issue=4|pages=1109–18|last2=Monczor|first2=F|last3=Baldi|first3=A|last4=Davio|first4=C|last5=Shayo|first5=C|doi=10.1124/mol.108.045336|s2cid=21485434 |hdl=11336/25894|hdl-access=free}}</ref><ref>{{cite journal|pmid=18761715|year=2008|last1=Threlfell|first1=S|title=Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra|journal=Journal of Neurochemistry|volume=107|issue=3|pages=745–55|last2=Exley|first2=R|last3=Cragg|first3=S. J|last4=Greenfield|first4=S. A|doi=10.1111/j.1471-4159.2008.05646.x|doi-access=free}}</ref>


==References==
==References==
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