Eric H. Davidson: Difference between revisions

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}}</ref> Davidson is best known for his pioneering work on the role of gene regulation in [[evolution]], on embryonic specification and for spearheading the effort to sequence the genome of the [[purple sea urchin]], ''Strongylocentrotus purpuratus''.<ref>{{cite journal | author=Sea urchin genome sequencing consortium | title=The genome of the sea urchin Strongylocentrotus purpuratus | journal="Science" | year=2006 | volume=314 | pmid=17095691 | pages=941–952 | issue=5801 | doi=10.1126/science.1133609}}</ref><ref>{{cite journal | author=Hood, L. | title=Gene regulatory networks and embryonic specification | journal=Proc. Natl. Acad. U.S.A. | volume=105 | pmid=18417452 | pages=5955–62 | year=2008 | issue=16 | doi=10.1073/pnas.0801434105 | pmc=2329716}}</ref> He has devoted a large part of his life to developing an understanding of [[embryogenesis]] at the genetic level. Over his long career, he has written many books describing his work.
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}}</ref> Davidson is best known for his pioneering work on the role of gene regulation in [[evolution]], on embryonic specification and for spearheading the effort to sequence the genome of the [[purple sea urchin]], ''Strongylocentrotus purpuratus''.<ref>{{cite journal | author=Sea urchin genome sequencing consortium | title=The genome of the sea urchin Strongylocentrotus purpuratus | journal="Science" | year=2006 | volume=314 | pmid=17095691 | pages=941–952 | issue=5801 | doi=10.1126/science.1133609}}</ref><ref>{{cite journal | author=Hood, L. | title=Gene regulatory networks and embryonic specification | journal=Proc. Natl. Acad. U.S.A. | volume=105 | pmid=18417452 | pages=5955–62 | year=2008 | issue=16 | doi=10.1073/pnas.0801434105 | pmc=2329716}}</ref> He has devoted a large part of his life to developing an understanding of [[embryogenesis]] at the genetic level. Over his long career, he has written many academic works describing his work, including a textbook on early animal development.<ref>{{cite book | author=Davidson, E.H. | title=Gene Activity in Early Development | year=1987 | publisher=Academic Press}}</ref>
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==Early Career==
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Davidson began conducting research as a teenager at [[Woods Hole Oceanographic Institute]].<ref>{{cite video | title=Evolution - The Molecular Landscape Interview with Eric Davidson | url=http://www.scivee.tv/node/11693 |date=2011-03-28}}</ref> After graduating from high school, he matriculated to the [[University of Pennsylvania]] and graduated with a B.A. in biology in 1958.<ref>{{cite web | url = http://www.its.caltech.edu/~mirsky/ehdavidson.htm
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| title = Eric H. Davidson
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}}</ref> Davidson's Ph.D. work entailed studying RNA synthesis and gene expression in early development of the anuran [[Xenopus laevis]] in the lab of [[Alfred Mirsky]] at [[Rockefeller University]].<ref>{{cite |author=Davidson, E.H., Allfrey, V.G. and Mirsky, A.E. |title=On the RNA synthesized during the lampbrush phase of amphibian oogenesis |year=1964 |journal=PNAS |volume=52 |pages=501-508}}</ref>
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==From Rockefeller to Caltech==
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After obtaining his Ph.D., Davidson stayed on at Rockefeller first as a research associate and then as an assistant professor. In 1971, he moved to the [[California Institute of Technology]] as an associate professor. There, Davidson took an interest in development of marine invertebrates, especially of the purple sea urchin [[Strongylocentrotus purpuratus]], and in investigating the function of genomic repetitive DNA elements, both interests of which would lead to a long line of investigation that eventually led to his contemporary interest in gene regulatory networks.<ref>{{cite book |title=Genomic Regulatory Systems: Development and Evolution |year=2001 |publisher=Academic Press}}</ref>
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==Career in Biology==
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Davidson has spent the majority of his scientific career investigating the molecular and mechanistic basis of animal development, i.e. how animals are built by reading the instructions encoded in the egg and, ultimately, in the genome. While at Rockefeller and very early in his career, he and Roy Britten, then at the Carnegie Institution of Washington, speculated on how the products of transcription, e.g. various RNAs or other downstream products, would need to in principle interact in order for cellular differentiation and gene regulation to occur in multicellular organisms.<ref>{{cite journal | doi=10.1126/science.165.3891.349 | author=Britten R. and E.H. Davidson | title=Gene regulation for higher cells: a theory | journal=Science | volume=165 | pages=349–57 | pmid=5789433 | year=1969 | issue=891}}</ref> This research program eventually led him to investigations regarding the role of gene regulation in cell lineage and embryonic territory specification, both endeavors of which contributed substantially to many biological disciplines, including [[developmental biology]], [[systems biology]] and [[evolutionary developmental biology]].
   
 
==Selected bibliography==
  
==Selected bibliography==

Revision as of 09:12, 29 March 2011

Prof. Eric H. Davidson
Born 1937
Residence Pasadena, CA United States
Nationality American United States
Fields Developmental biology
Institutions California Institute of Technology
Alma mater University of Pennsylvania (BA, 1958) and Rockefeller University (Ph.D., 1963)
Doctoral advisor Alfred Mirsky
Known for Gene regulatory networks, Sea Urchin Developmental biology
Notable awards Alexander von Humboldt Foundation Awardee, A.O Kowalevsky Medal (2002)
Notes

Eric H. Davidson (born 1937) is a developmental biologist at the California Institute of Technology.[1] Davidson is best known for his pioneering work on the role of gene regulation in evolution, on embryonic specification and for spearheading the effort to sequence the genome of the purple sea urchin, Strongylocentrotus purpuratus.[2][3] He has devoted a large part of his life to developing an understanding of embryogenesis at the genetic level. Over his long career, he has written many academic works describing his work, including a textbook on early animal development.[4]

Early Career

Davidson began conducting research as a teenager at Woods Hole Oceanographic Institute.[5] After graduating from high school, he matriculated to the University of Pennsylvania and graduated with a B.A. in biology in 1958.[6] Davidson's Ph.D. work entailed studying RNA synthesis and gene expression in early development of the anuran Xenopus laevis in the lab of Alfred Mirsky at Rockefeller University.[7]

From Rockefeller to Caltech

After obtaining his Ph.D., Davidson stayed on at Rockefeller first as a research associate and then as an assistant professor. In 1971, he moved to the California Institute of Technology as an associate professor. There, Davidson took an interest in development of marine invertebrates, especially of the purple sea urchin Strongylocentrotus purpuratus, and in investigating the function of genomic repetitive DNA elements, both interests of which would lead to a long line of investigation that eventually led to his contemporary interest in gene regulatory networks.[8]

Career in Biology

Davidson has spent the majority of his scientific career investigating the molecular and mechanistic basis of animal development, i.e. how animals are built by reading the instructions encoded in the egg and, ultimately, in the genome. While at Rockefeller and very early in his career, he and Roy Britten, then at the Carnegie Institution of Washington, speculated on how the products of transcription, e.g. various RNAs or other downstream products, would need to in principle interact in order for cellular differentiation and gene regulation to occur in multicellular organisms.[9] This research program eventually led him to investigations regarding the role of gene regulation in cell lineage and embryonic territory specification, both endeavors of which contributed substantially to many biological disciplines, including developmental biology, systems biology and evolutionary developmental biology.

Selected bibliography

  • Britten R. and E.H. Davidson (1969). "Gene regulation for higher cells: a theory". Science. 165 (891): 349–57. PMID 5789433. doi:10.1126/science.165.3891.349. 
  • Gene Activity in Early Development (1987) ISBN 0122051610
  • Genomic Regulatory Systems: Development and Evolution (2001) ISBN 0122053516
  • Davidson, E.H., J.P. Rast, P. Oliveri; et al. (2002). "A genomic regulatory network for development". Science. 295 (5560): 1669–78. PMID 11872831. doi:10.1126/science.1069883. 
  • The Regulatory Genome: Gene Regulatory Networks In Development And Evolution (2006) ISBN 0120885638

Notes

  1. ^ "Eric H. Davidson". 
  2. ^ Sea urchin genome sequencing consortium (2006). "The genome of the sea urchin Strongylocentrotus purpuratus". "Science". 314 (5801): 941–952. PMID 17095691. doi:10.1126/science.1133609. 
  3. ^ Hood, L. (2008). "Gene regulatory networks and embryonic specification". Proc. Natl. Acad. U.S.A. 105 (16): 5955–62. PMC 2329716 Freely accessible. PMID 18417452. doi:10.1073/pnas.0801434105. 
  4. ^ Davidson, E.H. (1987). Gene Activity in Early Development. Academic Press. 
  5. ^ Evolution - The Molecular Landscape Interview with Eric Davidson. 2011-03-28. 
  6. ^ "Eric H. Davidson". 
  7. ^ Davidson, E.H., Allfrey, V.G. and Mirsky, A.E. (1964), "On the RNA synthesized during the lampbrush phase of amphibian oogenesis", PNAS, 52: 501–508 
  8. ^ Genomic Regulatory Systems: Development and Evolution. Academic Press. 2001. 
  9. ^ Britten R. and E.H. Davidson (1969). "Gene regulation for higher cells: a theory". Science. 165 (891): 349–57. PMID 5789433. doi:10.1126/science.165.3891.349. 

External links

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