David Browne wrote that this song is about underrating Eminem himself: "In songs like the trudging 'Till I Collapse (...) he tells how persecuted he's been by the government, how his lyrics are constantly misinterpreted, and how I'll probably never get the props I deserve. DX Magazine called this song "massive hand-clap driven beat." Steve Juon wrote favourable review: "Wrapping up the album are "Till I Collapse," another surprisingly militaresque track." Kris Ex described "'Till I Collapse" as an "all paranoid horror-movie instrumentation bottomed with arena-rock grandeur." On October 9th, 2013, Watchmojo.com rated 'Till I Collapse number 7 on their Top 10 Eminem songs.
Although "'Till I Collapse" was not released as a single, when the single "Shake That" (also featuring Nate Dogg) was released in 2006, several Eminem songs recharted that same week, including this one. It charted in the UK at number 192 on 15 April 2006. In 2008, it appeared in HBO's Oscar De la Hoya - Manny Pacquiao 24/7. In 2009, it was used in an advert for the then-upcoming game Call of Duty: Modern Warfare 2. It raised digital download sales of the song worldwide considerably, but in Britain the song sold so many copies after the advert aired that it recharted that week (21 November 2009) at number 73, a new peak. During the 2010-2011 NBA season, the song was used during the Cleveland Cavaliers' team introductions. Shane Mosley used this song as an entrance theme with his bout with Floyd Mayweather as did Shane Carwin for his bout against Junior dos Santos. Major League Baseball pitcher Jesse Litsch used the song as his entrance music during the 2011 season. The song has also been used in the credits of the Season 8 premiere of Entourage. It was also used in September 2011 in the trailer and soundtrack for the film Real Steel, and in trailers and TV spots for the Oliver Stone-directed film Savages.