Özdemir Pasha (died 1561, Sana, Yemen Eyalet) was a Circassian Mamluk general for the Ottoman Empire. He joined Hadım Süleyman Pasha's campaign to India in 1538 (see Ottoman naval expeditions in the Indian Ocean). Later he became the Ottoman governor of Yemen and invaded Medri Bahri in 1557 for the Ottoman Empire.But he was defeated by Bahr negus Yeshaq.
Özdemir Pasha was well-regarded for bringing some measure of stability in the otherwise difficult-to-govern Yemeni eyalet. Under his supervision, cities were garrisoned, fortresses were built and the trade routes were secured. His rule was cut short by his death in 1561 in Sana, Yemen. Ten years later, his remains were reburied in the local Ottoman cemetery in Massawa, Abyssinia Eyalet (now Eritrea), where they lie to this day.