Ōkawa Station opened on 10 March 1926, as a freight-handling station on the privately held Tsurumi Rinko Railway (鶴見臨港鉄道,Tsurumi Rinko Tetsudo). Passenger services started on October 28, 1930. The line was nationalized on July 1, 1943, and was later absorbed into the Japanese National Railways (JNR) network. The station has been unattended since March 1, 1971. With the privatization of JNR on April 1, 1987, the station came under the control of JR East.