She was born on 23 June 1923 in Riga, to singer Erna Heine. An uncle, Alberts Verners, was a leading baritone for the Latvian National Opera in the 1930s for which Heine-Vāgnere also performed. She studied under singers Hertas Lūses and Marijas Bolotovas.
Heine-Vāgnere began her career in 1950 and appeared in Macbeth as Lady Macbeth, Cavalleria rusticana as Santuzza, Otello as Desdemona, Eugene Onegin as Tatyana, Der Ring des Nibelungen as Brünnhilde and Lohengrin as Ortrud. Other performances included roles in Alfrēds Kalniņš's Banuta, Salome, and Turandot. She retired in November 1975, having sang in 39 distinct roles.
Heine-Vāgnere was named a People's Artist of the USSR in 1969 and also received the Order of the Three Stars, third class. She was married to architect Nikolajs Vāgners and died on 7 December 2017, aged 94.
- "Mirusi operdziedātāja Žermēna Heine-Vāgnere" (in Latvian). Delfi. 7 December 2017. Retrieved 8 December 2017.
- "Mūžībā aizgājusi operdziedātāja Žermēna Heine-Vāgnere" (in Latvian). juans.lv. 7 December 2017. Archived from the original on 9 December 2017. Retrieved 8 December 2017. Alt URL