(R)-2-haloacid dehalogenase

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EC number
CAS number 119345-29-8
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In enzymology, a (R)-2-haloacid dehalogenase (EC, DL-2-haloacid halidohydrolase (inversion of configuration), DL-DEXi, (R,S)-2-haloacid dehalogenase (configuration-inverting)) is an enzyme that catalyzes the chemical reaction

(R)-2-haloacid + H2O \rightleftharpoons (S)-2-hydroxyacid + halide

Thus, the two substrates of this enzyme are (R)-2-haloacid and H2O, whereas its two products are (S)-2-hydroxyacid and halide.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is (R)-2-haloacid halidohydrolase. Other names in common use include 2-haloalkanoic acid dehalogenase[ambiguous], 2-haloalkanoid acid halidohydrolase[ambiguous], D-2-haloacid dehalogenase, and D-DEX.


  • Smith JM, Harrison K, Colby J (1990). "Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23". J. Gen. Microbiol. 136 (5): 881–6. doi:10.1099/00221287-136-5-881. PMID 2380688. 
  • Leigh JA, Skinner AJ and Cooper RA (1988). "Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species". FEMS Microbiol. Lett. 49 (3): 353–356. doi:10.1111/j.1574-6968.1988.tb02756.x. 
  • M, Tsunasawa S and Esaki N (1996). "Bacterial 2-haloacid dehalogenases: Structures and catalytic properties". Pure Appl. Chem. 68 (11): 2097–2103. doi:10.1351/pac199668112097.