(R)-2-hydroxy-fatty-acid dehydrogenase

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(R)-2-hydroxy-fatty-acid dehydrogenase
Identifiers
EC number 1.1.1.98
CAS number 37250-32-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a (R)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.98) is an enzyme that catalyzes the chemical reaction

(R)-2-hydroxystearate + NAD+ 2-oxostearate + NADH + H+

Thus, the two substrates of this enzyme are (R)-2-hydroxystearate and NAD+, whereas its 3 products are 2-oxostearate, NADH, and H+. This reaction is important in fatty acid metabolism.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include D-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.

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