(RNA-polymerase)-subunit kinase

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RNA polymerase subunit kinase
EC number2.7.11.23
CAS number122097-00-1
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a [RNA-polymerase]-subunit kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + [DNA-directed RNA polymerase] ADP + phospho-[DNA-directed RNA polymerase]

Thus, the two substrates of this enzyme are ATP and DNA-directed RNA polymerase, whereas its two products are ADP and [[phospho-[DNA-directed RNA polymerase]]].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[DNA-directed RNA polymerase] phosphotransferase. Other names in common use include CTD kinase, and STK9.


  • Lee JM, Greenleaf AL (1989). "A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 86 (10): 3624–8. doi:10.1073/pnas.86.10.3624. PMC 287190. PMID 2657724.