(acyl-carrier-protein) phosphodiesterase

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[acyl-carrier-protein] phosphodiesterase
EC no.
CAS no.37288-21-4
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a [acyl-carrier-protein] phosphodiesterase (EC is an enzyme that catalyzes the chemical reaction

holo-[acyl-carrier-protein] + H2O 4'-phosphopantetheine + apo-[acyl-carrier-protein]

Thus, the two substrates of this enzyme are [[holo-[acyl-carrier-protein]]] and H2O, whereas its two products are 4'-phosphopantetheine and [[apo-[acyl-carrier-protein]]].

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4'-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5B and 1TIK.


  • Sobhy C (1979). "Regulation of fatty acid synthetase activity. The 4'-phosphopantetheine hydrolase of rat liver". J. Biol. Chem. 254 (17): 8561–6. PMID 224058.
  • Vagelos PR, Larrabes AR (1967). "Acyl carrier protein. IX. Acyl carrier protein hydrolase". J. Biol. Chem. 242 (8): 1776–81. PMID 4290442.
  • Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization". J. Biol. Chem. 280 (41): 34675–83. doi:10.1074/jbc.M505736200. PMID 16107329.