(phosphorylase) phosphatase

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EC no.
CAS no.9025-74-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a [phosphorylase] phosphatase (EC is an enzyme that catalyzes the chemical reaction

[phosphorylase a] + 4 H2O 2 [phosphorylase b] + 4 phosphate

Thus, the two substrates of this enzyme are phosphorylase a and H2O, whereas its two products are phosphorylase b and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [phosphorylase a] phosphohydrolase. Other names in common use include PR-enzyme, phosphorylase a phosphatase, glycogen phosphorylase phosphatase, protein phosphatase C, and type 1 protein phosphatase.


  • Brandt H, Capulong ZL, Lee EY (1975). "Purification and properties of rabbit liver phosphorylase phosphatase". J. Biol. Chem. 250 (20): 8038–44. PMID 240850.
  • GRAVES DJ, FISCHER EH, KREBS EG (1960). "Specificity studies on muscle phosphorylase phosphatase". J. Biol. Chem. 235: 805–9. PMID 13829077.
  • RALL TW, WOSILAIT WD, SUTHERLAND EW (1956). "The interconversion of phosphorylase a and phosphorylase b from dog heart muscle". Biochim. Biophys. Acta. 20 (1): 69–76. doi:10.1016/0006-3002(56)90264-5. PMID 13315351.